Burden of primary influenza and respiratory syncytial virus pneumonia in hospitalised adults: insights from a 2-year multi-centre cohort study (2017-2018).

Viral community-acquired pneumonia (CAP) is a potentially serious illness, particularly in adult patients with underlying chronic conditions. In addition to the most recent SARS-CoV-2, influenza, and respiratory syncytial virus (RSV) are considered the most relevant causes of viral CAP. To describe the clinical features of hospitalised adults admitted for influenza-A/B and RSV pneumonia and analyse, according to aetiology, factors associated with non-invasive ventilation (NIV) failure and in-hospital death (IHD). This was a retrospective and multi-centre study of all adults who were admitted for laboratory-confirmed influenza-A/B or RSV pneumonia, during two consecutive winter seasons (October-April 2017-2018 and 2018-2019) in three tertiary hospitals in Portugal, Italy and Cyprus. A total of 356 adults were included in the study. Influenza-A, influenza-B and RSV were deemed to cause pneumonia in 197 (55.3%), 85 (23.9%) and 74 (20.8%) patients, respectively. Patients with both obstructive sleep apnoea or obesity hypoventilation syndrome and influenza-A virus pneumonia showed a higher risk for NIV failure (odds ratio (OR) 4.66; 95% confidence interval (CI) 1.42-15.30). Patients submitted to NIV showed a higher risk for IHD, regardless of comorbidities (influenza-A OR 3.00; 95% CI 1.35-6.65, influenza-B OR 4.52; 95% CI 1.13-18.01, RSV OR 5.61; 95% CI 1.26-24.93). The increased knowledge of influenza-A/B and RSV pneumonia burden may contribute to a better management of patients with viral CAP.

Boattini M ，Charrier L ，Almeida A ，Christaki E ，Moreira Marques T ，Tosatto V ，Bianco G ，Iannaccone M ，Tsiolakkis G ，Karagiannis C ，Maikanti P ，Cruz L ，Antão D ，Moreira MI ，Cavallo R ，Costa C ... -  《-》

Influenza and respiratory syncytial virus infections in the oldest-old continent.

Boattini M ，Almeida A ，Christaki E ，Cruz L ，Antão D ，Moreira MI ，Bianco G ，Iannaccone M ，Tsiolakkis G ，Khattab E ，Kasapi D ，Charrier L ，Tosatto V ，Marques TM ，Cavallo R ，Costa C ... -  《-》

Severity of RSV infection in Southern European elderly patients during two consecutive winter seasons (2017-2018).

In Europe, the respiratory syncytial virus (RSV) surveillance system is very heterogeneous and there is growing evidence of the importance of RSV infections resulting in hospitalization of elderly patients. The aim of this study was to assess the severity of RSV infection in the elderly living in the aged Southern European countries. We conducted a retrospective study of elderly patients ( ≥65-year old) admitted for laboratory-confirmed RSV infection in three tertiary hospitals in Portugal, Italy, and Cyprus over two consecutive winter seasons (2017-2018). Uni-multivariable analyses were carried out to evaluate the effect of clinical variables on radiologically confirmed pneumonia, use of noninvasive ventilation (NIV), and in-hospital death (IHD). A total of 166 elderly patients were included. Pneumonia was evident in 29.5%. NIV was implemented in 16.3%, length of stay was 11.8 ± 12.2 days, and IHD occurred in 12.1%. Multivariable analyses revealed that the risk of pneumonia was higher in patients with chronic kidney disease (CKD) (odds ratio [OR]: 2.57; 95% confidence interval [CI]: 1.12-5.91); the use of NIV was higher in patients with obstructive sleep apnea or obesity hypoventilation syndrome (OSA or OHS) (OR: 5.38; 95% CI: 1.67-17.35) and CKD (OR: 2.52; 95% CI: 1.01-6.23); the risk of IHD was higher in males (OR: 3.30; 95% CI: 1.07-10.10) and in patients with solid neoplasm (OR: 9.06; 95% CI: 2.44-33.54) and OSA or OHS (OR: 8.39; 95% CI: 2.14-32.89). Knowledge of factors associated with RSV infection severity may aid clinicians to set priorities and reduce disease burden. Development of effective antiviral treatment and vaccine against RSV is highly desirable.

Boattini M ，Almeida A ，Christaki E ，Marques TM ，Tosatto V ，Bianco G ，Iannaccone M ，Tsiolakkis G ，Karagiannis C ，Maikanti P ，Cruz L ，Antão D ，Moreira MI ，Cavallo R ，Costa C ... -  《-》

Severity of Respiratory Syncytial Virus vs COVID-19 and Influenza Among Hospitalized US Adults.

Surie D ，Yuengling KA ，DeCuir J ，Zhu Y ，Lauring AS ，Gaglani M ，Ghamande S ，Peltan ID ，Brown SM ，Ginde AA ，Martinez A ，Mohr NM ，Gibbs KW ，Hager DN ，Ali H ，Prekker ME ，Gong MN ，Mohamed A ，Johnson NJ ，Srinivasan V ，Steingrub JS ，Leis AM ，Khan A ，Hough CL ，Bender WS ，Duggal A ，Bendall EE ，Wilson JG ，Qadir N ，Chang SY ，Mallow C ，Kwon JH ，Exline MC ，Shapiro NI ，Columbus C ，Vaughn IA ，Ramesh M ，Mosier JM ，Safdar B ，Casey JD ，Talbot HK ，Rice TW ，Halasa N ，Chappell JD ，Grijalva CG ，Baughman A ，Womack KN ，Swan SA ，Johnson CA ，Lwin CT ，Lewis NM ，Ellington S ，McMorrow ML ，Martin ET ，Self WH ，Investigating Respiratory Viruses in the Acutely Ill (IVY) Network ... -  《JAMA Network Open》

Characteristics and outcomes of patients hospitalized for infection with influenza, SARS-CoV-2 or respiratory syncytial virus in the season 2022/2023 in a large German primary care centre.

Quarg C ，Jörres RA ，Engelhardt S ，Alter P ，Budweiser S ... -  《-》