Predicting length of stay and mortality among hospitalized patients with type 2 diabetes mellitus and hypertension.

Type 2 diabetes mellitus (T2DM) and hypertension (HTN), both non-communicable diseases, are leading causes of death globally, with more imbalances in lower middle-income countries. Furthermore, poor treatment and management are known to lead to intensified healthcare utilization and increased medical care costs and impose a significant societal burden, in these countries, including Indonesia. Predicting future clinical outcomes can determine the line of treatment and value of healthcare costs, while ensuring effective patient care. In this paper, we present the prediction of length of stay (LoS) and mortality among hospitalized patients at a tertiary referral hospital in Tasikmalaya, Indonesia, between 2016 and 2019. We also aimed to determine how socio-demographic characteristics, and T2DM- or HTN-related comorbidities affect inpatient LoS and mortality. We analyzed insurance claims data of 4376 patients with T2DM or HTN hospitalized in the referral hospital. We used four prediction models based on machine-learning algorithms for LoS prediction, in relation to disease severity, physician-in-charge, room type, co-morbidities, and types of procedures performed. We used five classifiers based on multilayer perceptron (MLP) to predict inpatient mortality and compared them according to training time, testing time, and Area under Receiver Operative Curve (AUROC). Classifier accuracy measures, which included positive predictive value (PPV), negative predictive value (NPV), F-Measure, and recall, were used as performance evaluation methods. A Random forest best predicted inpatient LoS (R2, 0.70; root mean square error [RMSE], 1.96; mean absolute error [MAE], 0.935), and the gradient boosting regression model also performed similarly (R2, 0.69; RMSE, 1.96; MAE, 0.935). For inpatient mortality, best results were observed using MLP with back propagation (AUROC 0.899; 69.33 and 98.61 for PPV and NPV, respectively). The other classifiers, stochastic gradient descent with regression loss function, Huber, and random forest models all showed an average performance. Linear regression model best predicted LoS and mortality was best predicted using MLP. Patients with primary diseases such as T2DM or HTN may have comorbidities that can prolong inpatient LoS. Physicians play an important role in disseminating health related information. These predictions could assist in the development of health policies and strategies that reduce disease burden in resource-limited settings.

Barsasella D ，Gupta S ，Malwade S ，Aminin ，Susanti Y ，Tirmadi B ，Mutamakin A ，Jonnagaddala J ，Syed-Abdul S ... -  《-》

A Machine Learning Model to Predict Length of Stay and Mortality among Diabetes and Hypertension Inpatients.

Barsasella D ，Bah K ，Mishra P ，Uddin M ，Dhar E ，Suryani DL ，Setiadi D ，Masturoh I ，Sugiarti I ，Jonnagaddala J ，Syed-Abdul S ... -  《-》

Prediction of mortality risk and duration of hospitalization of COVID-19 patients with chronic comorbidities based on machine learning algorithms.

The severity of coronavirus (COVID-19) in patients with chronic comorbidities is much higher than in other patients, which can lead to their death. Machine learning (ML) algorithms as a potential solution for rapid and early clinical evaluation of the severity of the disease can help in allocating and prioritizing resources to reduce mortality. The objective of this study was to predict the mortality risk and length of stay (LoS) of patients with COVID-19 and history of chronic comorbidities using ML algorithms. This retrospective study was conducted by reviewing the medical records of COVID-19 patients with a history of chronic comorbidities from March 2020 to January 2021 in Afzalipour Hospital in Kerman, Iran. The outcome of patients, hospitalization was recorded as discharge or death. The filtering technique used to score the features and well-known ML algorithms were applied to predict the risk of mortality and LoS of patients. Ensemble Learning methods is also used. To evaluate the performance of the models, different measures including F1, precision, recall, and accuracy were calculated. The TRIPOD guideline assessed transparent reporting. This study was performed on 1291 patients, including 900 alive and 391 dead patients. Shortness of breath (53.6%), fever (30.1%), and cough (25.3%) were the three most common symptoms in patients. Diabetes mellitus(DM) (31.3%), hypertension (HTN) (27.3%), and ischemic heart disease (IHD) (14.2%) were the three most common chronic comorbidities of patients. Twenty-six important factors were extracted from each patient's record. Gradient boosting model with 84.15% accuracy was the best model for predicting mortality risk and multilayer perceptron (MLP) with rectified linear unit function (MSE = 38.96) was the best model for predicting the LoS. The most common chronic comorbidities among these patients were DM (31.3%), HTN (27.3%), and IHD (14.2%). The most important factors in predicting the risk of mortality were hyperlipidemia, diabetes, asthma, and cancer, and in predicting LoS was shortness of breath. The results of this study showed that the use of ML algorithms can be a good tool to predict the risk of mortality and LoS of patients with COVID-19 and chronic comorbidities based on physiological conditions, symptoms, and demographic information of patients. The Gradient boosting and MLP algorithms can quickly identify patients at risk of death or long-term hospitalization and notify physicians to do appropriate interventions.

Amiri P ，Montazeri M ，Ghasemian F ，Asadi F ，Niksaz S ，Sarafzadeh F ，Khajouei R ... -  《-》

Predictors of in-hospital length of stay among cardiac patients: A machine learning approach.

The In-hospital length of stay (LOS) is expected to increase as cardiovascular diseases complexity increases and the population ages. This will affect healthcare systems especially with the current situation of decreased bed capacity and increasing costs. Therefore, accurately predicting LOS would have a positive impact on healthcare metrics. The aim of this study is to develop a machine learning-based model approach for predicting in-hospital LOS for cardiac patients. Using electronic medical records, we retrospectively extracted all records of patients' visits that were admitted under adult cardiology service. Admission diagnosis and primary treating physician were reviewed to verify selection criteria. A predictive machine learning-based model approach was applied to incorporate simple baseline health data at admission time to predict LOS. Patients were divided into three groups based on their LOS: short (<3 days), intermediate (3-5 days) and long (>5 days). Information gain algorithm was utilized to select the most relevant attributes. Only attributes with information gain of more than zero were used in model building. Four different machine learning techniques were evaluated and their diagnostic accuracy measures were compared. The dataset of this study included adult patients who were admitted between 2008 and 2016 in King Abdulaziz Cardiac Center (KACC). The center is located in King Abdulaziz Medical City Complex in Riyadh, the capital of Saudi Arabia. A total of 16,414 consecutive inpatient visits for 12,769 unique patients (mean age of 58.8 ± 16 years of which 68.2% were males) between 2008 and 2016 were included. The study cohort had a high prevalence of cardiovascular risk factors (hypertension 56%, diabetes 56%, dyslipidemia 52%, obesity 33% and smoking 24%). The most common admitting diagnosis was acute coronary syndrome (36%). The variables with highest impact on the prediction of in-hospital LOS were on admission heart rate, on admission systolic and diastolic blood pressure, age and insurance status (eligibility). Using machine learning models; Random Forest (RF) model outperformed among all other models (sensitivity (0.80), accuracy (0.80), and AUROC (0.94)). We showed that machine learning methods provide accurate prediction of LOS for cardiac patients. This is can be used in clinical bed management and resources allocation.

Daghistani TA ，Elshawi R ，Sakr S ，Ahmed AM ，Al-Thwayee A ，Al-Mallah MH ... -  《-》

Machine learning-based prediction of hospital prolonged length of stay admission at emergency department: a Gradient Boosting algorithm analysis.

Zeleke AJ ，Palumbo P ，Tubertini P ，Miglio R ，Chiari L ... -  《-》