Multiomics: unraveling the panoramic landscapes of SARS-CoV-2 infection.

In response to emerging infectious diseases, such as the recent pandemic of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), it is critical to quickly identify and understand responsible pathogens, risk factors, host immune responses, and pathogenic mechanisms at both the molecular and cellular levels. The recent development of multiomic technologies, including genomics, proteomics, metabolomics, and single-cell transcriptomics, has enabled a fast and panoramic grasp of the pathogen and the disease. Here, we systematically reviewed the major advances in the virology, immunology, and pathogenic mechanisms of SARS-CoV-2 infection that have been achieved via multiomic technologies. Based on well-established cohorts, omics-based methods can greatly enhance the mechanistic understanding of diseases, contributing to the development of new diagnostics, drugs, and vaccines for emerging infectious diseases, such as COVID-19.

Wang X ，Xu G ，Liu X ，Liu Y ，Zhang S ，Zhang Z ... -  《-》

Multiomics integration-based molecular characterizations of COVID-19.

The coronavirus disease 2019 (COVID-19) pandemic, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), rapidly became a global health challenge, leading to unprecedented social and economic consequences. The mechanisms behind the pathogenesis of SARS-CoV-2 are both unique and complex. Omics-scale studies are emerging rapidly and offer a tremendous potential to unravel the puzzle of SARS-CoV-2 pathobiology, as well as moving forward with diagnostics, potential drug targets, risk stratification, therapeutic responses, vaccine development and therapeutic innovation. This review summarizes various aspects of understanding multiomics integration-based molecular characterizations of COVID-19, which to date include the integration of transcriptomics, proteomics, genomics, lipidomics, immunomics and metabolomics to explore virus targets and developing suitable therapeutic solutions through systems biology tools. Furthermore, this review also covers an abridgment of omics investigations related to disease pathogenesis and virulence, the role of host genetic variation and a broad array of immune and inflammatory phenotypes contributing to understanding COVID-19 traits. Insights into this review, which combines existing strategies and multiomics integration profiling, may help further advance our knowledge of COVID-19.

Li CX ，Gao J ，Zhang Z ，Chen L ，Li X ，Zhou M ，Wheelock ÅM ... -  《-》

Role of Multiomics Data to Understand Host-Pathogen Interactions in COVID-19 Pathogenesis.

Aggarwal S ，Acharjee A ，Mukherjee A ，Baker MS ，Srivastava S ... -  《-》

Kinetic Multi-omic Analysis of Responses to SARS-CoV-2 Infection in a Model of Severe COVID-19.

Cantwell AM ，Singh H ，Platt M ，Yu Y ，Lin YH ，Ikeno Y ，Hubbard G ，Xiang Y ，Gonzalez-Juarbe N ，Dube PH ... -  《-》

Host-Virus Chimeric Events in SARS-CoV-2-Infected Cells Are Infrequent and Artifactual.

Yan B ，Chakravorty S ，Mirabelli C ，Wang L ，Trujillo-Ochoa JL ，Chauss D ，Kumar D ，Lionakis MS ，Olson MR ，Wobus CE ，Afzali B ，Kazemian M ... -  《-》