Continuous clinical improvement of mild-to-moderate seborrheic dermatitis and rebalancing of the scalp microbiome using a selenium disulfide-based shampoo after an initial treatment with ketoconazole.

Scalp seborrheic dermatitis (SD) is a chronic, relapsing, and inflammatory scalp disease. Studies indicate a global bacterial and fungal microbiota shift of scalp SD, as compared to healthy scalp. Ketoconazole and selenium disulfide (SeS2 ) improve clinical signs and symptoms in both scalp dandruff and SD. The main objective of this study was to investigate the changes in the scalp microbiota diversity and counts in subjects with scalp SD during a two-phase treatment period. The scalp microbiota and clinical efficacy were investigated in 68 subjects with mild-to-moderate scalp SD after an initial one-month treatment with 2% ketoconazole, and after a 2-month maintenance phase, either with a 1% SeS2 -based shampoo or its vehicle. Thirty one subjects in the active and 37 subjects in the vehicle group participated. Ketoconazole provided an improvement of clinical symptoms (adherent (-1.75 p < 0.05), non-adherent (-1.5, p < 0.05)) flakes and erythema (scores 1.67-0.93, p < 0.001), in an increased fungal diversity and in a significant (p < 0.005) decrease of Malassezia spp. SeS2 provided an additional clinical improvement (-0.8; p = 0.0002 and -0.7; p = 0.0081 for adherent and non-adherent flakes, respectively, at Day 84) compared to the vehicle associated with a low Malassezia spp. count and an additional significant (p < 0.001) decrease of the Staphylococcus spp. level. Selenium disulfide provides an additional benefit on the scalp microbiota and in clinical symptoms of SD and dandruff after treatment with ketoconazole. The results confirm the role of Staphylococcus spp. in scalp SD and open possible perspectives for preventing relapses.

Massiot P ，Clavaud C ，Thomas M ，Ott A ，Guéniche A ，Panhard S ，Muller B ，Michelin C ，Kerob D ，Bouloc A ，Reygagne P ... -  《-》

Maintenance effect of a once-weekly regimen of a Selenium Disulfide-based shampoo in moderate-to-severe scalp seborrheic dermatitis after initial treatment with topical corticosteroid/salicylic acid.

Massiot P ，Reygagne P ，Chagnoleau C ，Kanoun-Copy L ，Pouradier F ，Loussouarn G ，Queille-Roussel C ，Jouni H ，Kerob D ... -  《-》

A randomized, double-blind, placebo-controlled trial of ketoconazole 2% shampoo versus selenium sulfide 2.5% shampoo in the treatment of moderate to severe dandruff.

Danby FW ，Maddin WS ，Margesson LJ ，Rosenthal D ... -  《JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY》

Selenium Disulfide-based shampoo applied for 4 weeks significantly improves dandruff and seborrheic dermatitis.

Turcu G ，Artenie C ，Nowicka D ，Arenbergerová M ，Lazaridou E ，Khobzei K ，Ataseven A ，Part M ，Leclerc-Mercier S ... -  《-》

Selenium disulfide: a key ingredient to rebalance the scalp microbiome and sebum quality in the management of dandruff.

Clavaud C ，Michelin C ，Pourhamidi S ，Ziane S ，El Rawadi C ，Muller B ，Souverain L ，Panhard S ，Jourdain R ，Massiot P ，Martin R ，Isard O ，Cabirol F ，Drillon D ，Breton L ，Pouradier F ，Aguilar L ，Loussouarn G ，Gueniche A ... -  《-》