Long-term weight gain in obese COPD patients participating in a disease management program: a risk factor for reduced health-related quality of life.

Little is known about how long-term weight gain affects the health perception of COPD patients. The aim is to evaluate the long-term association of BMI change and health-related quality of life (HRQoL) in obese COPD patients. Claims and survey data from a COPD disease management program were used to match two groups of COPD patients with BMI ≥ 30 who have differing weight trajectories over a 5-year timespan via propensity score and genetic matching. EQ-5D-5L, including visual analog scale (VAS) and COPD Assessment Test (CAT), were used as outcomes of interest. Sociodemographic and disease-based variables were matched. Out of 1202 obese COPD patients, 126 with a weight increase of four or more BMI points were matched separately with 252 (propensity score matching) and 197 (genetic matching) control subjects who had relatively stable BMI. For the EQ-5D-5L, patients with BMI increase reported significantly worse health perception for VAS and all descriptive dimensions except pain/discomfort. For the CAT, especially the perception of ability to complete daily activities and overall energy results were significantly worse. VAS differences reach the range of minimal important differences. Stopping smoking and already being in obesity class II were the most influential risk factors for BMI increase. Obese COPD patients who gain four or more BMI points over 5 years report significantly lower results in different dimensions of generic and disease-specific HRQoL than their peers with stable BMI. To improve real-world outcomes, tracking and preventing specific BMI trajectories could constitute a clinically relevant aspect of managing COPD patients.

Huber MB ，Schneider N ，Kirsch F ，Schwarzkopf L ，Schramm A ，Leidl R ... -  《RESPIRATORY RESEARCH》

The relationship between body mass index and health-related quality of life in COPD: real-world evidence based on claims and survey data.

Huber MB ，Kurz C ，Kirsch F ，Schwarzkopf L ，Schramm A ，Leidl R ... -  《RESPIRATORY RESEARCH》

Measuring health-related quality of life in chronic obstructive pulmonary disease: properties of the EQ-5D-5L and PROMIS-43 short form.

Lin FJ ，Pickard AS ，Krishnan JA ，Joo MJ ，Au DH ，Carson SS ，Gillespie S ，Henderson AG ，Lindenauer PK ，McBurnie MA ，Mularski RA ，Naureckas ET ，Vollmer WM ，Lee TA ，CONCERT Consortium ... -  《BMC Medical Research Methodology》

Validity of EQ-5D utility index and minimal clinically important difference estimation among patients with chronic obstructive pulmonary disease.

Bae E ，Choi SE ，Lee H ，Shin G ，Kang D ... -  《BMC Pulmonary Medicine》

Does quality of life of COPD patients as measured by the generic EuroQol five-dimension questionnaire differentiate between COPD severity stages?

Rutten-van Mölken MP ，Oostenbrink JB ，Tashkin DP ，Burkhart D ，Monz BU ... -  《CHEST》