Interplay between MAPK/ERK signaling pathway and MicroRNAs: A crucial mechanism regulating cancer cell metabolism and tumor progression.

Mitogen-activated protein kinase (MAPK) signal transduction, as a highly conserved signaling pathway, is reported to be involved in various biological events, including metabolic reprogramming, cell proliferation, survival, and differentiation. Mutations in key molecules involved in MAPK/ERK signaling and dysregulation of this pathway are very common events in various human malignancies, which make the MAPK signaling a crucial signaling pathway participating in the regulation of glucose uptake by malignant cells and tumorigenesis. MicroRNAs (miRNAs), as small non-coding RNAs, are critical regulators of gene expression that play key roles in cancer initiation and progression. On the other hand, these small RNAs mutually regulate the MAPK signaling which is often overexpressed in the case of cancer progression; suggesting that crosstalk between miRNAs and this signaling pathway plays a pivotal role in the development of human cancers. Some miRNAs such as miR-20b, miR-34c-3p, miR-152, miR-181a, and miR-302b through inhibiting MAPK signaling, and miR-193a-3p, miR-330-3p, and miR-592 by activating this signaling pathway, play imperative roles in tumorigenesis. Therefore, in this review, we aimed to focus on the interplay between miRNAs and MAPK signaling in the various steps of tumorigenesis, including metabolic regulation, cell proliferation, apoptosis, metastasis, angiogenesis, and drug resistance.

Asl ER ，Amini M ，Najafi S ，Mansoori B ，Mokhtarzadeh A ，Mohammadi A ，Lotfinejad P ，Bagheri M ，Shirjang S ，Lotfi Z ，Rasmi Y ，Baradaran B ... -  《-》

MiR-20b Displays Tumor-Suppressor Functions in Papillary Thyroid Carcinoma by Regulating the MAPK/ERK Signaling Pathway.

Hong S ，Yu S ，Li J ，Yin Y ，Liu Y ，Zhang Q ，Guan H ，Li Y ，Xiao H ... -  《-》

Circular RNA MAPK4 (circ-MAPK4) inhibits cell apoptosis via MAPK signaling pathway by sponging miR-125a-3p in gliomas.

He J ，Huang Z ，He M ，Liao J ，Zhang Q ，Wang S ，Xie L ，Ouyang L ，Koeffler HP ，Yin D ，Liu A ... -  《Molecular Cancer》

MicroRNA-330-3p promotes cell invasion and metastasis in non-small cell lung cancer through GRIA3 by activating MAPK/ERK signaling pathway.

Wei CH ，Wu G ，Cai Q ，Gao XC ，Tong F ，Zhou R ，Zhang RG ，Dong JH ，Hu Y ，Dong XR ... -  《Journal of Hematology & Oncology》

Poor expression of microRNA-135b results in the inhibition of cisplatin resistance and proliferation and induces the apoptosis of gastric cancer cells through MST1-mediated MAPK signaling pathway.

Zhou J ，Chen Q 《-》