Epitranscriptomic(N6-methyladenosine) Modification of Viral RNA and Virus-Host Interactions.

N6-methyladenosine (m6A) is the most prevalent and internal modification of eukaryotic mRNA. Multiple m6A methylation sites have been identified in the viral RNA genome and transcripts of DNA viruses in recent years. m6A modification is involved in all the phases of RNA metabolism, including RNA stability, splicing, nuclear exporting, RNA folding, translational modulation, and RNA degradation. Three protein groups, methyltransferases (m6A-writers), demethylases (m6A-erasers), and m6A-binding proteins (m6A-readers) regulate this dynamic reversible process. Here, we have reviewed the role of m6A modification dictating viral replication, morphogenesis, life cycle, and its contribution to disease progression. A better understanding of the m6A methylation process during viral pathogenesis is required to reveal novel approaches to combat the virus-associated diseases.

Imam H ，Kim GW ，Siddiqui A 《Frontiers in Cellular and Infection Microbiology》

Association of N6-methyladenosine with viruses and virally induced diseases.

Wu F ，Cheng W ，Zhao F ，Tang M ，Diao Y ，Xu R ... -  《-》

Association of N6-methyladenosine with viruses and related diseases.

Wu F ，Cheng W ，Zhao F ，Tang M ，Diao Y ，Xu R ... -  《Virology Journal》

Regulatory effect of m(6) A modification on different viruses.

N6 -methyladenosine (m6 A) modification is the most common and reversible posttranscriptional modification of RNA in eukaryotes, which is mainly regulated by methyltransferase, demethylase, and specific binding protein. The replication of the virus and host immune response to the virus are affected by m6 A modification. In different kinds of viruses, m6 A modification has two completely opposite regulatory functions. This paper reviews the regulatory effects of m6 A modification on different viruses and provides a reference for studying the regulatory effects of RNA epitranscriptomic modification.

Yu PL ，Cao SJ ，Wu R ，Zhao Q ，Yan QG ... -  《-》

Hepatitis B Virus X Protein Expression Is Tightly Regulated by N6-Methyladenosine Modification of Its mRNA.

Kim GW ，Siddiqui A 《-》