Seroprevalence of SARS-CoV-2 antibodies and associated factors in healthcare workers: a systematic review and meta-analysis.

Healthcare workers (HCWs) represent a high-risk population for infection with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). To determine the seroprevalence of SARS-CoV-2 antibodies among HCWs, and identify the factors associated with this seroprevalence. The Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines were applied for this systematic review and meta-analysis. Databases including PubMed/MEDLINE and preprint services (medRχiv and bioRχiv) were searched from inception to 24th August 2020. Forty-nine studies including 127,480 HCWs met the inclusion criteria. The estimated overall seroprevalence of SARS-CoV-2 antibodies among HCWs was 8.7% (95% confidence interval 6.7-10.9%). Seroprevalence was higher in studies conducted in North America (12.7%) compared with those conducted in Europe (8.5%), Africa (8.2) and Asia (4%). Meta-regression showed that increased sensitivity of antibody tests was associated with increased seroprevalence. The following factors were associated with seropositivity: male gender; Black, Asian and Hispanic HCWs; work in a coronavirus disease 2019 (COVID-19) unit; patient-related work; front-line HCWs; healthcare assistants; shortage of personal protective equipment; self-reported belief of previous SARS-CoV-2 infection; previous positive polymerase chain reaction test; and household contact with suspected or confirmed cases of COVID-19. The seroprevalence of SARS-CoV-2 antibodies among HCWs is high. Excellent adherence to infection prevention and control measures; sufficient and adequate personal protective equipment; and early recognition, identification and isolation of HCWs infected with SARS-CoV-2 are imperative to decrease the risk of SARS-CoV-2 infection.

Galanis P ，Vraka I ，Fragkou D ，Bilali A ，Kaitelidou D ... -  《-》

Seroprevalence of SARS-CoV-2 antibodies in healthcare workers at a London NHS Trust.

Grant JJ ，Wilmore SMS ，McCann NS ，Donnelly O ，Lai RWL ，Kinsella MJ ，Rochford HL ，Patel T ，Kelsey MC ，Andrews JA ... -  《-》

The seroprevalence of SARS-CoV-2 antibodies among health care workers before the era of vaccination: a systematic review and meta-analysis.

The prevalence of SARS-CoV-2 infection among health care workers (HCWs) provides information about the spread of COVID-19 within health care facilities, and the risk groups. We aimed to describe the rate of SARS-CoV-2 seroprevalence and its determinants among HCWs. We used Web of Science, PubMed, Scopus, MEDLINE, EBSCOhost and Cochrane Library. We included the reports of SARS-CoV-2 seroprevalence with a sample size of minimum 1000 HCWs. The study was registered at the International Prospective Register of Systematic Reviews (PROSPERO, no. CRD42021230456). We used PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) statement. The keywords were "COVID-19", "SARS-CoV-2", "Coronavirus", "seroprevalence", "health care workers" and "risk factors". In total 4329 reports were retrieved, duplications were removed; after filtering according to the title and abstract, 25 studies were selected. Risk of bias was assessed in 25 studies; it was low in 13 studies, medium in four studies, and high in eight studies. In meta-analysis using the random effect model, the weighted average of seroprevalence was calculated as 8% (95% CI 6-10%). The pooled seroprevalence rates of the selected variables that have a rate above the average were male HCWs with 9% (95% CI 7-11%); HCWs from ethnic minorities with 13% (95% CI 9-17%); high exposure 9% (95% CI 6-13%); exposure to the virus outside the health care setting 22% (95% CI 14-32%). Our analysis indicates a SARS-CoV-2 seroprevalence rate of 8% among studies that included >1000 HCWs for the year 2020, before vaccinations started. The most common risk factors associated with higher seroprevalence rate were ethnicity, male gender and having a higher number of household contacts. Working as a frontline HCW was inconsistent in its association with higher seroprevalence.

Kayı İ ，Madran B ，Keske Ş ，Karanfil Ö ，Arribas JR ，Psheniсhnaya N ，Petrosillo N ，Gönen M ，Ergönül Ö ... -  《-》

Global seroprevalence of SARS-CoV-2 antibodies: A systematic review and meta-analysis.

Bobrovitz N ，Arora RK ，Cao C ，Boucher E ，Liu M ，Donnici C ，Yanes-Lane M ，Whelan M ，Perlman-Arrow S ，Chen J ，Rahim H ，Ilincic N ，Segal M ，Duarte N ，Van Wyk J ，Yan T ，Atmaja A ，Rocco S ，Joseph A ，Penny L ，Clifton DA ，Williamson T ，Yansouni CP ，Evans TG ，Chevrier J ，Papenburg J ，Cheng MP ... -  《PLoS One》

Seroprevalence of SARS-CoV-2 IgG antibodies and risk factors in health care workers at an academic medical center in Boston, Massachusetts.

Kataria Y ，Cole M ，Duffy E ，de la Cena K ，Schechter-Perkins EM ，Bouton TC ，Werler MM ，Pierre C ，Ragan EJ ，Weber SE ，Jacobson KR ，Andry C ... -  《Scientific Reports》