Neurogenic rosacea in Korea.

Rosacea with severe neurological symptoms such as burning and stinging is often not treated effectively by conventional therapies. The aim of this study was to investigate the clinical characteristics of Korean rosacea patients with prominent neurological symptoms. The demographic features, medical history, clinical manifestations and treatment modalities of 17 neurogenic rosacea patients who had prominent neurological symptoms and 106 erythematotelangiectatic rosacea (ETR) patients as a control group were investigated. All 17 neurogenic rosacea patients had severe persistent erythema with burning/stinging sensation limited to both cheeks. Among these patients, 94.1% were female (16/17). Heat stimuli (58.8%, 10/17) and stress (52.9%, 9/17) were major aggravating factors. Fourteen of 17 patients (82.3%) improved after receiving anticonvulsants and antidepressants. In conclusion, rosacea patients with severe neurological symptoms show distinct clinical manifestations and should be classified separately, and a different therapeutic approach is necessary for them.

Kim HO ，Kang SY ，Kim KE ，Cho SY ，Kim KH ，Kim IH ... -  《-》

Neurogenic Rosacea Treatment: A Literature Review.

Ivanic MG ，Oulee A ，Norden A ，Javadi SS ，Gold MH ，Wu JJ ... -  《Journal of Drugs in Dermatology》

Clinical, Histologic, and Molecular Analysis of Differences Between Erythematotelangiectatic Rosacea and Telangiectatic Photoaging.

Helfrich YR ，Maier LE ，Cui Y ，Fisher GJ ，Chubb H ，Fligiel S ，Sachs D ，Varani J ，Voorhees J ... -  《-》

Differences in clinical characteristics of rosacea across age groups: A retrospective study of 840 female patients.

Aging remains a common influencing factor for many diseases. Previous studies have shown that age is significantly associated with rosacea among female cases and that the incidence of rosacea increases with age. However, previous studies did not specifically analyze the clinical characteristics of different age groups. This study aimed to analyze and compare the clinical characteristics of female patients of rosacea among different age groups. We conducted a retrospective study of 840 female rosacea subjects and compared cutaneous features, aggravating factors, systemic diseases, and psychological states across age groups. The patients were divided into three groups according to their age at diagnosis: ≤30 years，31-44 years，and ≥45 years. In our study, the mean age of subjects was 35.9 ± 10.23 years. The common symptoms included telangiectasia (82.6%), persistent erythema (82.0%), burning/stinging sensation (89.3%), dry sensation (74.0%), and pruritis (41.9%). Hot temperature (89.9%), emotional changes (67.3%), spicy food (55.6%), and sun exposure (50.7%) were the common aggravating factors. Some patients had comorbidities of systemic disorders (20.4%). Of the patients, 48.8% presented with anxiety and 35.2% with depression. The clinical characteristics were found to be significantly different among the different age groups. Middle-aged and older patients (≥45 years) were more likely to have more serious persistent erythema and telangiectasia. And these patients were relatively less affected by some of the influencing factors and had more systemic diseases of the digestive system, endocrine metabolic system, and cardiovascular system (p < 0.05). We revealed the impact of age on the characteristics of rosacea, which indicated that the clinical features of rosacea are more complex and more difficult to treat in females over the age of 45.

Yang F ，Wang L ，Shucheng H ，Jiang X ... -  《-》

Cross-Sectional Survey of the Burden of Illness of Rosacea by Erythema Severity.

Harper J ，Del Rosso JQ ，Ferrusi IL 《Journal of Drugs in Dermatology》