The Emerging Role of Neutrophil Extracellular Traps (NETs) in Tumor Progression and Metastasis.

Neutrophil Extracellular Traps (NETs) are net-like structures composed of DNA-histone complexes and proteins released by activated neutrophils. In addition to their key role in the neutrophil innate immune response, NETs are also involved in autoimmune diseases, like systemic lupus erythematosus, rheumatoid arthritis, psoriasis, and in other non-infectious pathological processes, as coagulation disorders, thrombosis, diabetes, atherosclerosis, vasculitis, and cancer. Recently, a large body of evidence indicates that NETs are involved in cancer progression and metastatic dissemination, both in animal models and cancer patients. Interestingly, a close correlation between cancer cell recruitment of neutrophils in the tumor microenvironment (Tumor Associated Neutrophils. TANs) and NET formation has been also observed either in primary tumors and metastatic sites. Moreover, NETs can also catch circulating cancer cells and promote metastasis. Furthermore, it has been reported that wake dormant cancer cells, causing tumor relapse and metastasis. This review will primarily focus on the pro-tumorigenic activity of NETs in tumors highlighting their ability to serve as a potential target for cancer therapy.

Masucci MT ，Minopoli M ，Del Vecchio S ，Carriero MV ... -  《Frontiers in Immunology》

Primary tumors induce neutrophil extracellular traps with targetable metastasis promoting effects.

Rayes RF ，Mouhanna JG ，Nicolau I ，Bourdeau F ，Giannias B ，Rousseau S ，Quail D ，Walsh L ，Sangwan V ，Bertos N ，Cools-Lartigue J ，Ferri LE ，Spicer JD ... -  《JCI Insight》

NETscape or NEThance: tailoring anti-cancer therapy.

Neutrophils, major regulators of innate immunity, have recently emerged as key components of the tumor microenvironment. The role of neutrophils in cancer has been linked to their ability to form neutrophil extracellular traps (NETs), structures composed of decondensed DNA decorated with enzymes that are released into the extracellular space. Here, we discuss the pivotal roles of NETs in influencing responses to anticancer therapies such as chemotherapy, radiotherapy, immunotherapy, and targeted therapy. Highlighting recent insights, we delve into the dual nature of NETs in the context of anticancer treatments, examining their potential to either counteract or enhance treatment outcomes. Strategic targeting of NETs may be a promising avenue for crafting combination therapies to counteract resistance or enhance anticancer treatments' efficacy.

Mousset A ，Bellone L ，Gaggioli C ，Albrengues J ... -  《Trends in Cancer》

Influence of Interleukin-8 and Neutrophil Extracellular Trap (NET) Formation in the Tumor Microenvironment: Is There a Pathogenic Role?

Gonzalez-Aparicio M ，Alfaro C 《-》

Neutrophil Elastase and Neutrophil Extracellular Traps in the Tumor Microenvironment.

Huang H ，Zhang H ，Onuma AE ，Tsung A ... -  《-》