Early triglyceride and glucose index as a risk marker for gestational diabetes mellitus.

To assess the risk of gestational diabetes mellitus (GDM) according to the triglyceride and glucose (TyG) index values during the first trimester of pregnancy in Latin American women. Pregnant women were enrolled at their first prenatal visit at the Obstetric Division in the University Hospital "Dr. José E. González". Triglycerides and fasting plasma glucose (FPG) were collected to determine the TyG index. GDM diagnosis was performed by a single-step 2-hour 75-g oral glucose tolerance test. Generalized linear models were used to determine risk ratios; pregnancy outcomes at delivery were collected from the hospital medical records. A total of 164 pregnant women were included. GDM was present in 29 (17.7%) women. No significant differences in age, first-trimester body mass index (BMI, calculated as weight in kilograms divided by the square of height in meters), family history of diabetes, and TyG index were observed between GDM cases and the reference group without GDM. The adjusted analysis showed no association between TyG and GDM (risk ratio [RR] 1.03, 95% confidence interval [CI] 0.57-1.88]). Higher TyG index values between women with and without a diagnosis of GDM in the second trimester were observed. No significant differences were identified in pregnancy outcomes, although a trend was observed for hyperbilirubinemia in women with first-trimester TyG index values greater than 8.7. Our findings do not support the use of the TyG index for GDM prediction in Latin American women.

Sánchez-García A ，Rodríguez-Gutiérrez R ，Saldívar-Rodríguez D ，Guzmán-López A ，Mancillas-Adame L ，González-Nava V ，Santos-Santillana K ，González-González JG ... -  《-》

Triglyceride and glucose index and the risk of gestational diabetes mellitus: A nationwide population-based cohort study.

Pre-pregnancy insulin resistance is one of the main pathophysiologies of gestational diabetes mellitus (GDM). Triglyceride-glucose (TyG) index is a marker of insulin resistance. We aimed to evaluate the association between pre-pregnancy TyG index and GDM in primipara women. A total of 380,208 women who underwent a Korean national health screening exam within 2 years before their first delivery, between January 1, 2012 and December 31, 2015, were included. The TyG index was calculated as ln [triglyceride (mg/dL) × fasting plasma glucose (mg/dL)/2]. Among the 380,208 primipara women, 17,239 women were diagnosed with GDM (4.53%). Multivariate logistic regression analysis adjusted for risk factors showed a higher odds ratio of 1.73 for GDM (95% CI 1.65-1.81) in the highest quartile than that in the lowest quartile. A 1-SD increase in the TyG index increased the risk of GDM (31%) and GDM requiring insulin therapy (82%) in the fully adjusted model. A 1-unit increase in the TyG index significantly increased the risk of GDM and GDM requiring insulin treatment by 1.81 and 3.69 times, respectively.The impact of a high TyG index on the risk of GDM was more profound in the subjects aged ≥ 35 years, with obesity, with impaired fasting glucose, who are current smokers, and with a family history of diabetes mellitus. Increased pre-pregnancy TyG index is associated with a risk of GDM. Elevation of the TyG index may be an early marker of GDM.

Kim JA ，Kim J ，Roh E ，Hong SH ，Lee YB ，Baik SH ，Choi KM ，Noh E ，Hwang SY ，Cho GJ ，Yoo HJ ... -  《-》

Association of first-trimester maternal lipid profiles and triglyceride-glucose index with the risk of gestational diabetes mellitus and large for gestational age newborn.

Pazhohan A ，Rezaee Moradali M ，Pazhohan N 《-》

Maternal Serum Copper and Some Metabolic Indexes in Late Second Trimester of Gestational Diabetes Mellitus Pregnancy.

Genova MP ，Ivanova I ，Naseva E ，Velizarova M ，Atanasova B ... -  《Clinical Laboratory》

Diagnostic accuracy of the triglyceride-glucose index for gestational diabetes screening: a practical approach.

Sánchez-García A ，Rodríguez-Gutiérrez R ，Saldívar-Rodríguez D ，Guzmán-López A ，Castillo-Castro C ，Mancillas-Adame L ，Santos-Santillana K ，González-Nava V ，González-González JG ... -  《-》