The remarkable role of emulsifier and chitosan, dextran and PEG as capping agents in the enhanced delivery of curcumin by nanoparticles in breast cancer cells.

Curcumin has been found to be a powerful anti-cancer agent. However, its efficacy is limited by its poor solubility in aqueous medium. The bioavailability of curcumin was increased by poly (lactic-co-glycolic) acid [PLGA (60/40)] nanoparticles with different capping agents such as Chitosan, Dextran and PEG and emulsifier (Tocopherol Poly (Ethylene Glycol)1000 Succinate: TPGS) with good drug loading and delivery performance. The preparation of nanoparticles derived from PLGA was achieved by emulsion solvent evaporation method and the resultant nanoparticles were characterized. The encapsulation efficiency of curcumin by PLGA NPs with different capping agents such as Chitosan, PEG and Dextran and emulsifier lies in the range of 82% to 89% and the anti-oxidant activity is 80%. The in vitro anticancer activity of PLGA nanoparticles embedded with curcumin and different capping agents on MCF-7 indicates that they are more effective in arresting cell growth. The cellular uptake of TPGS emulsified dextran capped curcumin encapsulated PLGA NPs is much higher when compared to that of PLGA NPs with other capping agents, emulsifier and free curcumin.

Sampath M ，Pichaimani A ，Kumpati P ，Sengottuvelan B ... -  《-》

Using PVA and TPGS as combined emulsifier in nanoprecipitation method improves characteristics and anticancer activity of ibuprofen loaded PLGA nanoparticles.

Sahin A ，Spiroux F ，Guedon I ，Arslan FB ，Sarcan ET ，Ozkan T ，Colak N ，Yuksel S ，Ozdemir S ，Ozdemir B ，Akbas S ，Ultav G ，Aktas Y ，Capan Y ... -  《PHARMAZIE》

Surface-modified PLGA nanoparticles with PEG/LA-chitosan for targeted delivery of arsenic trioxide for liver cancer treatment: Inhibition effects enhanced and side effects reduced.

Arsenic trioxide (As2O3), an effective drug for leukemia, is limited to be used for solid tumor treatment due to its high side effects. In this study, polyethylene glycol (PEG) and lactobionic acid (LA) modified chitosan (PLC) was synthesized and was used to coat poly(lactide-co-glycolide) (PLGA) nanoparticles for encapsulation and targeted release of As2O3 in liver cancer treatment. The As2O3-loaded PLGA/PLC nanoparticles (As2O3-PLGA/PLC NPs) were fabricated through double emulsion-solvent evaporation method and were optimized by orthogonal tests. As2O3-PLGA/PLC NPs presented suitable physical stability, positive charge, high encapsulation efficiency and drug loading, and good biocompatibility. As expected, the NPs can quickly release enough dose of As2O3 in a short time and then sustain the drug concentration. The As2O3-PLGA/PLC NPs showed effective inhibition of SMMC-7721 cells while having lower cytotoxicity against normal human liver cells (LO2 cells). Furthermore, In vivo study showed that the NPs did not present toxic effects on kidney and liver, but showed relatively high growth inhibition effect on liver tumor. Therefore, this PLGA/PLC NPs could be an effective and safe drug delivery system for liver cancer chemotherapy.

Song X ，Wang J ，Xu Y ，Shao H ，Gu J ... -  《-》

Development of modular polymeric nanoparticles for drug delivery using amine reactive chemistry.

Wong C ，Ho EA 《JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES》

In Vitro and In Vivo Comparison of Curcumin-Encapsulated Chitosan-Coated Poly(lactic-co-glycolic acid) Nanoparticles and Curcumin/Hydroxypropyl-β-Cyclodextrin Inclusion Complexes Administered Intranasally as Therapeutic Strategies for Alzheimer's Disease.

Zhang L ，Yang S ，Wong LR ，Xie H ，Ho PC ... -  《-》