Signaling pathways targeting mitochondrial potassium channels.

In this review, we describe key signaling pathways regulating potassium channels present in the inner mitochondrial membrane. The signaling cascades covered here include phosphorylation, redox reactions, modulation by calcium ions and nucleotides. The following types of potassium channels have been identified in the inner mitochondrial membrane of various tissues: ATP-sensitive, Ca2+-activated, voltage-gated and two-pore domain potassium channels. The direct roles of these channels involve regulation of mitochondrial respiration, membrane potential and synthesis of reactive oxygen species (ROS). Changes in channel activity lead to diverse pro-life and pro-death responses in different cell types. Hence, characterizing the signaling pathways regulating mitochondrial potassium channels will facilitate understanding the physiological role of these proteins. Additionally, we describe in this paper certain regulatory mechanisms, which are unique to mitochondrial potassium channels.

Rotko D ，Kunz WS ，Szewczyk A ，Kulawiak B ... -  《-》

What do we not know about mitochondrial potassium channels?

In this review, we summarize our knowledge about mitochondrial potassium channels, with a special focus on unanswered questions in this field. The following potassium channels have been well described in the inner mitochondrial membrane: ATP-regulated potassium channel, Ca(2+)-activated potassium channel, the voltage-gated Kv1.3 potassium channel, and the two-pore domain TASK-3 potassium channel. The primary functional roles of these channels include regulation of mitochondrial respiration and the alteration of membrane potential. Additionally, they modulate the mitochondrial matrix volume and the synthesis of reactive oxygen species by mitochondria. Mitochondrial potassium channels are believed to contribute to cytoprotection and cell death. In this paper, we discuss fundamental issues concerning mitochondrial potassium channels: their molecular identity, channel pharmacology and functional properties. Attention will be given to the current problems present in our understanding of the nature of mitochondrial potassium channels. This article is part of a Special Issue entitled 'EBEC 2016: 19th European Bioenergetics Conference, Riva del Garda, Italy, July 2-6, 2016', edited by Prof. Paolo Bernardi.

Laskowski M ，Augustynek B ，Kulawiak B ，Koprowski P ，Bednarczyk P ，Jarmuszkiewicz W ，Szewczyk A ... -  《-》

Mitochondrial potassium channels.

Szewczyk A ，Jarmuszkiewicz W ，Kunz WS 《-》

[Mitochondrial ion channels].

Skalska J ，Debska-Vielhaber G ，Głab M ，Kulawiak B ，Malińska D ，Koszela-Piotrowska I ，Bednarczyk P ，Dołowy K ，Szewczyk A ... -  《-》

Mitochondrial ion channels/transporters as sensors and regulators of cellular redox signaling.

O-Uchi J ，Ryu SY ，Jhun BS ，Hurst S ，Sheu SS ... -  《-》