SNHG11 promotes cell proliferation in colorectal cancer by forming a positive regulatory loop with c-Myc.

Dysregulation of long non-coding RNAs (lncRNA) have long been linked to the onset and development of colorectal cancer (CRC), yet the underlying mechanisms remain elusive. Small nucleolar RNA host gene 11 (SNHG11) is a novel lncRNA with few information about its role in development and progression of CRC. Here, we found SNHG11, a highly conserved lncRNA, was commonly overexpressed in various cancer including CRC. High expression of SNHG11 correlated with poor prognosis in patients with CRC. Gain of function and loss-of function experiments showed that SNHG11 visibly promoted proliferation in CRC cells. Mechanistic assays revealed that SNHG11 interacted with Insulin-like growth factor 2 (IGF2) mRNA-binding protein 1 (IGF2BP1), thereby enhancing the interaction between IGF2BP1 and c-Myc mRNA, a well-known target of IGF2BP1. Consequently, c-Myc mRNA expression was stabilized and its downstream targets were significantly upregulated. Further investigation demonstrated that SNHG11 upregulated c-Myc which in turn transcriptionally upregulated SNHG11. Taken together, our findings suggested that reciprocal regulation of SNHG11 and c-Myc promotes cell proliferation in CRC.

Huang W ，Dong S ，Cha Y ，Yuan X ... -  《-》

The long non-coding RNA SNHG3 functions as a competing endogenous RNA to promote malignant development of colorectal cancer.

Huang W ，Tian Y ，Dong S ，Cha Y ，Li J ，Guo X ，Yuan X ... -  《-》

Long non-coding RNA GHET1 promotes gastric carcinoma cell proliferation by increasing c-Myc mRNA stability.

Yang F ，Xue X ，Zheng L ，Bi J ，Zhou Y ，Zhi K ，Gu Y ，Fang G ... -  《-》

SNHG15 is a bifunctional MYC-regulated noncoding locus encoding a lncRNA that promotes cell proliferation, invasion and drug resistance in colorectal cancer by interacting with AIF.

Saeinasab M ，Bahrami AR ，González J ，Marchese FP ，Martinez D ，Mowla SJ ，Matin MM ，Huarte M ... -  《JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH》

The long noncoding RNA LUCAT1 promotes colorectal cancer cell proliferation by antagonizing Nucleolin to regulate MYC expression.

Wu R ，Li L ，Bai Y ，Yu B ，Xie C ，Wu H ，Zhang Y ，Huang L ，Yan Y ，Li X ，Lin C ... -  《Cell Death & Disease》