Neonatal Late Onset Infection with Severe Acute Respiratory Syndrome Coronavirus 2.

 To date, no information on late-onset infection in newborns to mother with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) contracted in pregnancy are available. This study aimed to evaluate postdischarge SARS-CoV-2 status of newborns to mothers with COVID-19 in pregnancy that, at birth, were negative to SARS-CoV-2.  This is an observational study of neonates born to mothers with coronavirus disease 2019 (COVID-19).  Seven pregnant women with documented SARS-CoV-2 infection have been evaluated in our institution. One woman had a spontaneous abortion at 8 weeks of gestational age, four women recovered and are still in follow-up, and two women delivered. Two newborns were enrolled in the study. At birth and 3 days of life, newborns were negative to SARS-CoV-2. At 2-week follow-up, one newborn tested positive although asymptomatic.  Our findings highlight the importance of follow-up of newborns to mothers with COVID-19 in pregnancy, since they remain at risk of contracting the infection in the early period of life and long-term consequences are still unknown. · Newborns to mothers with coronavirus disease 2019 (COVID-19) in pregnancy can acquire the infection later after birth.. · Newborns to mothers with COVID-19 in pregnancy need a long-term follow-up, even if they tested negative at birth.. · Specific guidelines for the long-term follow-up of newborns to mothers with COVID-19 in pregnancy are needed..

Buonsenso D ，Costa S ，Sanguinetti M ，Cattani P ，Posteraro B ，Marchetti S ，Carducci B ，Lanzone A ，Tamburrini E ，Vento G ，Valentini P ... -  《-》

Characteristics of Newborns Born to SARS-CoV-2-Positive Mothers: A Retrospective Cohort Study.

The novel virus known as severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) has led to a terrifying pandemic. The range of illness severity among children is variable. This study aims to assess the characteristics of newborns born to SARS-CoV-2-positive women compared with those mothers who tested negative. This was a retrospective cohort study performed at Brookdale Hospital Medical Center in New York City from March to May 2020. Electronic medical records of mother-baby dyads were reviewed. Seventy-nine mothers tested for SARS-CoV-2 were included, out of which 18.98% of mothers tested SARS-CoV-2 positive. We found a significant association between symptoms and SARS-CoV-2 status. We observed a significant association between newborns of SARS-CoV-2 positive and SARS-CoV-2 negative mothers regarding skin-to-skin contact (p < 0.001). Both groups showed significant differences regarding isolation (p < 0.001). Interestingly, regarding SARS-CoV-2 infection in newborns, only one newborn tested SARS-CoV-2 positive and was unstable in the neonatal intensive care unit (NICU). With the multivariable logistic regression model, babies of SARS-CoV-2 positive mothers were three times as likely to have desaturations in comparison to newborns from negative mothers. Also, newborns of SARS-CoV-2-positive mothers were four times more likely to have poor feeding, compared with newborns of SARS-CoV-2-negative mothers. Finally, babies of SARS-CoV-2-positive mothers were ten times more likely to be symptomatic at the 2-week follow-up. SARS-CoV-2 has caused major morbidity and mortality worldwide. Neonates born to mothers with confirmed or suspected SARS-CoV-2 are most of the time asymptomatic. However, neonatal critical illness due to SARS-CoV-2 is still a possibility; thus, isolation precautions (such as avoiding skin-to-skin contact and direct breastfeeding) and vertical transmission should be studied thoroughly. In addition, testing these newborns by nasopharyngeal swab at least at 24 hours after birth and monitoring them for the development of symptoms for 14 days after birth is needed. · For SARS-CoV-2-positive mothers, reducing transmission of infection to newborns is crucial.. · Newborns of SARS-CoV-2-positive mothers are usually asymptomatic and may not be easily infected.. · Critical illness in the newborn may still happen, so monitoring is needed..

Farghaly MAA ，Kupferman F ，Castillo F ，Kim RM ... -  《-》

Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2) infection during late pregnancy: a report of 18 patients from Wuhan, China.

Zhang L ，Dong L ，Ming L ，Wei M ，Li J ，Hu R ，Yang J ... -  《BMC Pregnancy and Childbirth》

Outcomes of Neonates Born to Mothers With Severe Acute Respiratory Syndrome Coronavirus 2 Infection at a Large Medical Center in New York City.

Dumitriu D ，Emeruwa UN ，Hanft E ，Liao GV ，Ludwig E ，Walzer L ，Arditi B ，Saslaw M ，Andrikopoulou M ，Scripps T ，Baptiste C ，Khan A ，Breslin N ，Rubenstein D ，Simpson LL ，Kyle MH ，Friedman AM ，Hirsch DS ，Miller RS ，Fernández CR ，Fuchs KM ，Keown MK ，Glassman ME ，Stephens A ，Gupta A ，Sultan S ，Sibblies C ，Whittier S ，Abreu W ，Akita F ，Penn A ，D'Alton ME ，Orange JS ，Goffman D ，Saiman L ，Stockwell MS ，Gyamfi-Bannerman C ... -  《-》

Association of Maternal Perinatal SARS-CoV-2 Infection With Neonatal Outcomes During the COVID-19 Pandemic in Massachusetts.

Angelidou A ，Sullivan K ，Melvin PR ，Shui JE ，Goldfarb IT ，Bartolome R ，Chaudhary N ，Vaidya R ，Culic I ，Singh R ，Yanni D ，Patrizi S ，Hudak ML ，Parker MG ，Belfort MB ... -  《JAMA Network Open》