D-dimer/fibrinogen ratio for the prediction of progressive hemorrhagic injury after traumatic brain injury.

Progressive hemorrhagic injury (PHI) greatly affects prognosis of traumatic brain injury (TBI). D-dimer/fibrinogen ratio (D/F ratio) may be a potential predictor for venous thromboembolism. This study sought to describe and evaluate any relationship between D/F ratio and PHI after TBI. This retrospective study included a cohort of 192 TBI patients. Plasma D-dimer and fibrinogen were measured, and subsequently D/F ratio was calculated. Multivariate logistic regression analysis was applied to identify predictors of PHI. Receiver operating characteristic (ROC) curve was conFig.d to analyze predictive capability for PHI. A total of 43 patients (22.4%) experienced PHI. Both Glasgow coma scale (GCS) score (odds ratio [OR], 0.565; 95% CI, 0.464-0.689) and D/F ratio (OR, 4.026; 95% CI, 2.219-7.305) were the two independent predictor for PHI. Area under ROC curve (AUC) of D/F ratio was similar to that of GCS score (AUC, 0.816; 95% CI, 0.754-0.868 vs. AUC, 0.834; 95% CI, 0.773-0.883; P = 0.699). Moreover, D/F ratio significantly improved AUC of GCS score to 0.928 (95% CI, 0.881-0.960; P < 0.001). D/F ratio was strongly predictive of PHI in the studied cohort and, thereby should be considered in the clinical management of TBI patients.

Xu DX ，Du WT ，Li X ，Wu ZX ，Yu GF ... -  《-》

D-dimer as a predictor of progressive hemorrhagic injury in patients with traumatic brain injury: analysis of 194 cases.

Tian HL ，Chen H ，Wu BS ，Cao HL ，Xu T ，Hu J ，Wang G ，Gao WW ，Lin ZK ，Chen SW ... -  《-》

Ability of Fibrin Monomers to Predict Progressive Hemorrhagic Injury in Patients with Severe Traumatic Brain Injury.

Esnault P ，Mathais Q ，D'Aranda E ，Montcriol A ，Cardinale M ，Cungi PJ ，Goutorbe P ，Joubert C ，Dagain A ，Meaudre E ... -  《-》

A risk score based on admission characteristics to predict progressive hemorrhagic injury from traumatic brain injury in children.

Hu GW ，Lang HL ，Guo H ，Wu L ，Zhang P ，Kuang W ，Zhu XG ... -  《-》

Time Course of Coagulation and Fibrinolytic Parameters in Patients with Traumatic Brain Injury.

Nakae R ，Takayama Y ，Kuwamoto K ，Naoe Y ，Sato H ，Yokota H ... -  《-》