Comparing the performance of SOFA, TPA combined with SOFA and APACHE-II for predicting ICU mortality in critically ill surgical patients: A secondary analysis.

Total psoas muscle area (TPA) can indicate the status of the entire human body's skeletal muscle mass. It has been reported that lower TPA can increase the risk of mortality in critically ill patients. The aim of our study was to evaluate the relationship between TPA and ICU mortality and to compare the performance of Sequential Organ Failure Assessment (SOFA), TPA combined with SOFA and Acute Physiology, Chronic Health Evaluation (APACHE-II) for predicting ICU mortality in critically ill surgical patients. This study was a retrospective observational cohort study with a total of 96 critically ill surgical patients, ages 21-96 years old. Main outcome measures included difficult-to-wean (DTW), operation methods, ICU mortality, ICU stay, APACHE II, sepsis and SOFA. CT-scan assessed the TPA. It is acknowledged that the entire study was completed by Hao-Wei Kou et al. and the data were uploaded from plosone.com. The authors used this data only for secondary analysis. The results showed that TPA is a protective factor for ICU mortality (OR: 0.99 95% [0.99, 1.00], P = 0.0269). In addition, when we defined sarcopenia-based TPA, our study showed that sarcopenia increased the risk of ICU mortality (OR:3.73 (1.27, 10.98) P = 0.0167. Furthermore, discrimination of ICU mortality was significantly higher using SOFA (AUROC, 0.7810 [99% CI, 0.6658-0.8962]) than either TPA (AUROC, 0.7023 [99% CI, 0.5552-0.8494]) or APACHE II score (AUROC, 0.7447 [99% CI, 0.6289-0.8604]). Additionally, when we combined TPA with SOFA score, the ROC of TPA + SOFA (AUROC, 0.8647 [99% CI, 0.7881-0.9412]) was the highest when compared to the other three models. The relationship between TPA and ICU mortality is negative in critically ill surgical patients. In addition, the combination of TPA and SOFA was the best tool among the three scoring systems in providing significant discriminative ability when predicting ICU mortality in critically ill surgical patients.

Zhang XM ，Zhang WW ，Yu XZ ，Dou QL ，Cheng AS ... -  《-》

The effect of positive balance on the outcomes of critically ill noncardiac postsurgical patients: a retrospective cohort study.

Fluid balance remains a highly controversial topic in the critical care field, and no consensus has been reached about the fluid levels required by critically ill surgical patients. In this study, we investigated the relationship between fluid balance and in-hospital mortality in critically ill surgical patients. The medical records of adult patients managed in a surgical intensive care unit (ICU) for more than 48 hours after surgery from January 2010 to February 2011 were reviewed retrospectively. Abstracted data included body weights, Acute Physiology and Chronic Health Evaluation (APACHE) II scores, Sequential Organ Failure Assessment (SOFA) scores, fluid therapy values (intake, output, and balance) during the ICU stay, type of operation, length of stay in the ICU and hospital, and in-hospital mortality. A total of 148 patients were enrolled. The in-hospital mortality rate was 20.8%, and the median length of stay in the ICU and hospital were 5.0 and 24 days, respectively. The median daily fluid balance over the first 3 postoperative days was positive 11.2 mL/kg. Fluid balances in the ICU were 19.2, 15.0, and -0.6 mL kg(-1) d(-1), respectively, during the first 3 days vs SOFA scores (6.8, 6.3, and 6.5). Comparing the nonsurvival group with the survival group, the univariate analysis showed that age (P = .05), APACHE II score (P < .001), and use of a vasopressor (norepinephrine) (P = .05) affect in-hospital mortality. In the overall patients, any of the fluid balances were not significantly associated with mortality. However, in critically ill patients whose APACHE II scores were greater than 20, the nonsurvivor group showed a significant tendency toward a positive balance compared with the survivor group on the second and third days of ICU stay. Nevertheless, the SOFA scores showed no difference between nonsurvivor and survivors during the initial 2 postoperative days. In critically ill noncardiac postsurgical patients whose APAHCE II scores were greater than 20, a positive balance in the ICU can be associated with mortality risk. To determine the direct effect of positive fluid balance, a larger scaled, prospective randomized study will be required.

Shim HJ ，Jang JY ，Lee SH ，Lee JG ... -  《-》

The use of APACHE II, SOFA, SAPS 3, C-reactive protein/albumin ratio, and lactate to predict mortality of surgical critically ill patients: A retrospective cohort study.

Basile-Filho A ，Lago AF ，Menegueti MG ，Nicolini EA ，Rodrigues LAB ，Nunes RS ，Auxiliadora-Martins M ，Ferez MA ... -  《-》

Sequential Organ Failure Assessment (SOFA) Score for predicting mortality in patients with sepsis in Vietnamese intensive care units: a multicentre, cross-sectional study.

To compare the accuracy of the Sequential Organ Failure Assessment (SOFA) and Acute Physiology and Chronic Health Evaluation II (APACHE II) Scores in predicting mortality among intensive care unit (ICU) patients with sepsis in a low-income and middle-income country. A multicentre, cross-sectional study. A total of 15 adult ICUs throughout Vietnam. We included all patients aged ≥18 years who were admitted to ICUs for sepsis and who were still in ICUs from 00:00 to 23:59 of the specified study days (ie, 9 January, 3 April, 3 July and 9 October of the year 2019). The primary outcome was hospital all-cause mortality (hospital mortality). We also defined the secondary outcome as all-cause deaths in the ICU (ICU mortality). Of 252 patients, 40.1% died in hospitals, and 33.3% died in ICUs. SOFA Score (areas under the receiver operating characteristic curve (AUROC): 0.688 (95% CI 0.618 to 0.758); cut-off value≥7.5; PAUROC<0.001) and APACHE II Score (AUROC: 0.689 (95% CI 0.622 to 0.756); cut-off value ≥20.5; PAUROC<0.001) both had a poor discriminatory ability for predicting hospital mortality. However, the discriminatory ability for predicting ICU mortality of SOFA (AUROC: 0.713 (95% CI 0.643 to 0.783); cut-off value≥9.5; PAUROC<0.001) was fair and was better than that of APACHE II Score (AUROC: 0.672 (95% CI 0.603 to 0.742); cut-off value≥18.5; PAUROC<0.001). A SOFA Score≥8 (adjusted OR (AOR): 2.717; 95% CI 1.371 to 5.382) and an APACHE II Score≥21 (AOR: 2.668; 95% CI 1.338 to 5.321) were independently associated with an increased risk of hospital mortality. Additionally, a SOFA Score≥10 (AOR: 2.194; 95% CI 1.017 to 4.735) was an independent predictor of ICU mortality, in contrast to an APACHE II Score≥19, for which this role did not. In this study, SOFA and APACHE II Scores were worthwhile in predicting mortality among ICU patients with sepsis. However, due to better discrimination for predicting ICU mortality, the SOFA Score was preferable to the APACHE II Score in predicting mortality.Clinical trials registry - India: CTRI/2019/01/016898.

Do SN ，Dao CX ，Nguyen TA ，Nguyen MH ，Pham DT ，Nguyen NT ，Huynh DQ ，Hoang QTA ，Bui CV ，Vu TD ，Bui HN ，Nguyen HT ，Hoang HB ，Le TTP ，Nguyen LTB ，Duong PT ，Nguyen TD ，Le VH ，Pham GTT ，Bui GTH ，Bui TV ，Pham TTN ，Nguyen CV ，Nguyen AD ，Phua J ，Li A ，Luong CQ ... -  《BMJ Open》

[Comparison of four early warning scores in predicting the prognosis of critically ill patients in secondary hospitals].

Su X ，Zhang H ，Yuan W ，Yi M ，Fu C ，Jiang J ，Gao H ... -  《-》