Second-generation magnetically controlled capsule gastroscopy with improved image resolution and frame rate: a randomized controlled clinical trial (with video).

Compared with conventional endoscopy, magnetically controlled capsule gastroscopy (MCCG) can be further optimized in gastric examination time and complete visualization of upper GI (UGI) mucosa. The second-generation MCCG (MCCG-2) was developed with higher image resolution and adaptive frame rate, and we aimed to evaluate its clinical availability for UGI examination in this study. Consecutive patients undergoing MCCG examination between May to June 2019 were prospectively enrolled and randomized to swallow the first-generation MCCG (MCCG-1) or MCCG-2 in a 1:1 ratio. The main outcomes included visualization of the esophagus and duodenum, operation-related parameters, image quality, maneuverability, detection of lesions, and safety evaluation. Eighty patients were enrolled. In the MCCG-2 group, frames captured for esophageal mucosa and Z-line were 171.00 and 2.00, significantly increased from those in the MCCG-1 group (97.00 [P = .002] and .00 [P = .028], respectively). The gastric examination time was shortened from 7.78 ± .97 minutes to 5.27 ± .74 minutes (P < .001), with the total running time of the capsule extended from 702.83 minutes to 1001.99 minutes (P < .001). MCCG-2 also greatly improved the image quality (P < .001) and maneuverability (P < .01). No statistical difference existed in the detection of lesions between the 2 groups, and no adverse events occurred. MCCG-2 showed better performance in mucosal visualization, examination duration, and maneuverability, making better diagnosis of UGI diseases a possibility. (Clinical trial registration number: NCT03977935.).

Jiang B ，Qian YY ，Pan J ，Jiang X ，Wang YC ，Zhu JH ，Zou WB ，Zhou W ，Li ZS ，Liao Z ... -  《-》

Preliminary study of magnetically controlled capsule gastroscopy for diagnosing superficial gastric neoplasia.

Magnetically controlled capsule gastroscopy (MCCG) is a newly developed non-invasive method designed for gastric examination. Although favorable diagnostic accuracy has been reported, there is little if any data about its ability to diagnose gastric cancer. To compare the detectability of superficial gastric neoplasia by MCCG and gastroscopy. This study was a self-controlled comparison study. Ten subjects diagnosed with superficial gastric neoplasia and scheduled to undergo endoscopic submucosal dissection (ESD) at a tertiary hospital were prospectively invited for an MCCG examination. The diagnostic agreement of MCCG, ESD and pathology were compared, including location, size and endoscopic appearance of the lesions. Of the 10 enrolled patients, 6 were confirmed as having early gastric cancer/high-grade intraepithelial neoplasia, 2 gastric low-grade intraepithelial neoplasia (LGIN), 1 tubular adenoma with LGIN and 1 neuroendocrine tumor. The per-patient and per-lesion sensitivities of MCCG for superficial gastric neoplasia detection were 100% and 91.7%. Location and size of the lesions were compared favorably to gastroscopy whilst one cardiac lesion was missed. Endoscopic appearances of these lesions observed on MCCG and EGD demonstrated good consistency. No adverse events were observed. With good gastric preparation and careful examination of stomach, MCCG is able to detect superficial gastric neoplasms.

Qian YY ，Zhu SG ，Hou X ，Zhou W ，An W ，Su XJ ，McAlindon ME ，Li ZS ，Liao Z ... -  《-》

Repetitive Position Change Improves Gastric Cleanliness for Magnetically Controlled Capsule Gastroscopy.

Wang YC ，Pan J ，Jiang X ，Su XJ ，Zhou W ，Zou WB ，Qian YY ，Chen YZ ，Liu X ，Yu J ，Yan XN ，Zhao AJ ，Li ZS ，Liao Z ... -  《-》

[The China expert consensus of clinical practice for magnetically controlled capsule gastroscopy(2017, Shanghai)].

Chinese Digestive Endoscopist Committee ，Chinese Endoscopist Association, the Health Management and Physical Examination Committee of Digestive Endoscopy ，Capsule Endoscopy Collaboration Group of Chinese Society of Digestive Endoscopy ，Chinese Anti-Cancer Association, the Society of Oncological Endoscopy ，Chinese Society of Health Management ... -  《-》

Comparison between the widely used magnetically controlled capsule gastroscopy and conventional gastroscopy: a meta-analysis.

Hu J ，Wang X ，Sun S 《-》