Quantitative muscle MRI study of patients with sporadic inclusion body myositis.

Fat infiltration in individual muscles of sporadic inclusion body myositis (sIBM) patients has rarely been assessed. Sixteen sIBM patients were assessed using MRI of the thighs and lower legs (LL). The severity of fat infiltration, proximal-to-distal and side asymmetries, and the correlations with clinical and functional parameters were investigated. All the patients had fat-infiltrated muscles, and thighs were more severely affected than LL. A proximal-to-distal gradient of fat infiltration was mainly observed for adductors, quadriceps, sartorius, and medial gastrocnemius muscles. A strong negative correlation was observed between the whole muscle fat fraction in the thighs and LL and the Inclusion Body Myositis Functional Rating Scale and Medical Research Council scores for the lower limbs. Fat infiltration in individual muscles of sIBM patients is heterogeneous in terms of proximal-to-distal gradient and severity was correlated with clinical scores. These results should be considered for both natural history investigation and clinical trials.

Ansari B ，Salort-Campana E ，Ogier A ，Le Troter PhD A ，De Sainte Marie B ，Guye M ，Delmont E ，Grapperon AM ，Verschueren A ，Bendahan D ，Attarian S ... -  《-》

Quantitative muscle MRI in sporadic inclusion body myositis (sIBM): A prospective cohort study.

Schlaffke L ，Rehmann R ，Froeling M ，Güttsches AK ，Vorgerd M ，Enax-Krumova E ，Forsting J ... -  《-》

Magnetic resonance imaging of skeletal muscles in sporadic inclusion body myositis.

Cox FM ，Reijnierse M ，van Rijswijk CS ，Wintzen AR ，Verschuuren JJ ，Badrising UA ... -  《-》

Sporadic Inclusion Body Myositis: MRI Findings and Correlation With Clinical and Functional Parameters.

Guimaraes JB ，Zanoteli E ，Link TM ，de Camargo LV ，Facchetti L ，Nardo L ，Fernandes ADRC ... -  《-》

Fat fraction distribution in lower limb muscles of patients with CMT1A: A quantitative MRI study.

To quantitatively describe the MRI fat infiltration pattern of muscle degeneration in Charcot-Marie-Tooth (CMT) type 1A (CMT1A) disease and to look for correlations with clinical variables. MRI fat fraction was assessed in lower-limb musculature of patients with CMT1A and healthy controls. More particularly, 14 muscle compartments were selected at leg and thigh levels and for proximal, distal, and medial slices. Muscle fat infiltration profile was determined quantitatively in each muscle compartment and along the entire volume of acquisition to determine a length-dependent gradient of fat infiltration. Clinical impairment was evaluated with muscle strength measurements and CMT Examination Scores (CMTESs). A total of 16 patients with CMT1A were enrolled and compared to 11 healthy controls. Patients with CMT1A showed a larger muscle fat fraction at leg and thigh levels with a proximal-to-distal gradient. At the leg level, the largest fat infiltration was quantified in the anterior and lateral compartments. CMTES was correlated with fat fraction, especially in the anterior compartment of leg muscles. Strength of plantar flexion was also correlated with fat fraction of the posterior compartments of leg muscles. On the basis of quantitative MRI measurements combined with a dedicated segmentation method, muscle fat infiltration quantified in patients with CMT1A disclosed a length-dependent peroneal-type pattern of fat infiltration and was correlated to main clinical variables. Quantification of fat fraction at different levels of the leg anterior compartment might be of interest in future clinical trials.

Bas J ，Ogier AC ，Le Troter A ，Delmont E ，Leporq B ，Pini L ，Guye M ，Parlanti A ，Lefebvre MN ，Bendahan D ，Attarian S ... -  《-》