Phytochemical analysis of Holothuria leucospilota, a sea cucumber from Persian Gulf.

Sea cucumbers are widely consumed in traditional medicine and food. These animals have a considerable secondary metabolite and also several potential biological activities. This study investigated the phytochemical and cytotoxic evaluation of Holothuria leucospilota (H. leucospilota), a sea cucumber from Persian Gulf. The saponin composition of H. leucospilota was studied by different partitioning and chromatography methods such as thin layer chromatography (TLC), medium pressure liquid chromatography (MPLC) and high performance LC (HPLC). The marine sea cucumber Holostane-type triterpenoids (1-3) were characterized by physical and spectroscopic examination (1 and 2 dimensional neuclear magnetic resonance and mass experiments) with data analysis. The structure of compounds 1-3 identified as echinoside A, holothurine A, and 24-dehydroechinoside A, showed moderate cytotoxic activity with IC50 values of 1.9 ± 0.07, 6.8 ± 0.23, and 2.57 ± 0.18 μg/mL against HeLa and 10.4 ± 0.32, 8.9 ± 0.24, and 4.4 ± 0.13 on HUVEC cell line, respectively. In conclusion, the holostane-type triterpenoids showed moderate cytotoxic activity against HeLa cell line and have a prosperous future to be introduced as a lead structure.

Shushizadeh MR ，Mohammadi Pour P ，Mahdieh M ，Yegdaneh A ... -  《-》

Hemolytic and cytotoxic properties of saponin purified from Holothuria leucospilota sea cucumber.

Soltani M ，Parivar K ，Baharara J ，Kerachian MA ，Asili J ... -  《-》

Cancer Cell Inhibiting Sea Cucumber (Holothuria leucospilota) Protein as a Novel Anti-Cancer Drug.

Ru R ，Guo Y ，Mao J ，Yu Z ，Huang W ，Cao X ，Hu H ，Meng M ，Yuan L ... -  《Nutrients》

Heavy metal accumulation in tissues of two sea cucumbers, Holothuria leucospilota and Holothuria scabra in the northern part of Qeshm Island, Persian Gulf.

The concentrations of some heavy metals (Cd, Cu, Zn andPb) were investigated in the sediments and the two species of sea cucumber (Holothuria leucospilota and Holothuria scabra) from northern part of Qeshm Island, Persian Gulf. The levels of Cu, Zn and Pb in sediment varied significantly among sampling sites (p<0.05). The highest levels of Zn and Pb in H. leucospilota were recorded in body wall whereas the highest contents of Zn and Pb in H. scabra were measured in respiratory tree organ, respectively. Cu and Cd were the most abundant elements in gonads of H. leucospilota while highest levels of Cd and Cu in H. scabra were measured in the gonad and derm, respectively. Cu and Zn concentrations were below permissible limits for human consumption while Cd and Pb were above permissible limits for human consumption.

Mohammadizadeh M ，Bastami KD ，Ehsanpour M ，Afkhami M ，Mohammadizadeh F ，Esmaeilzadeh M ... -  《-》

Cytotoxic Screening of Marine Organisms from Persian Gulf.

Vaseghi G ，Hajakbari F ，Sajjadi S ，Dana N ，Ghasemi A ，Yegdaneh A ... -  《-》