Preconditioning with endoplasmic reticulum stress alleviated heart ischemia/reperfusion injury via modulating IRE1/ATF6/RACK1/PERK and PGC-1α in diabetes mellitus.

The purpose of this study was to observe the functions of preconditioning with endoplasmic reticulum stress (ERS) whether alleviated heart ischemia/reperfusion injury (HI/RI) via modulating IRE1/ATF6/RACK1/PERK and PGC-1α expressions in diabetes mellitus (DM) or not. Diabetic rats were pretreated with 0.6 mg/kg tunicamycin (TM, 0.6 mg/kg tunicamycin was administered via intraperitoneal injection 30 minutes prior to the I/R procedures), and then subjected to 45 minutes of ischemia and 3 hours of reperfusion. Blood and myocardial tissues were collected, myocardial pathological injuries were investigated, serum creatine kinase-MB (CK-MB) and cardiac troponin T (cTnT) levels were measured, left ventricular systolic pressure (LVSP), left ventricular end diastolic pressure (LVEDP), maximum rate of left ventricular pressure rise (+dp/dtmax) and maximum rate of left ventricular pressure drop (-dp/dtmax) were evaluated, reactive oxygen species (ROS) and caspase-3 levels were observed, ΔΨm level and ROS expression were measured, and activated transcript factor 6 (ATF6), receptor for activated C kinase 1 (RACK1), PRK-like ER kinase (PERK), glucose regulated protein 78 (GRP78) and peroxisome proliferator-activated receptor γ co-activator 1-α (PGC-1α) expressions were assessed. The TM ameliorated the pathological damages, reduced myocardial oxidative stress damages, restrained apoptosis, and upregulated the expressions of ATF6, RACK1, PERK, GRP78 and PGC-1α compared with those of the ischemia/reperfusion (I/R) group in DM. This study suggested the preconditioning with endoplasmic reticulum stress (TM) strategy that could enhance protection against HI/RI in DM in clinical myocardial diseases.

Yan B ，Liu S ，Li X ，Zhong Y ，Tong F ，Yang S ... -  《-》

Corilagin alleviated intestinal ischemia-reperfusion injury by modulating endoplasmic reticulum stress via bonding with Bip.

Wang Y ，Liu G ，Qiu F ，Li X ，Diao Y ，Yang M ，Yang S ，Li B ，Han Q ，Liu J ... -  《-》

[Effect and related mechanism of acetate in alleviating acute kidney injury in septic rats through G-protein coupled receptor 43].

Shi X ，Xing J ，Wang Y ，Li J ，Chai R ，Yu X ... -  《-》

Endoplasmic Reticulum Stress Induces ROS Production and Activates NLRP3 Inflammasome Via the PERK-CHOP Signaling Pathway in Dry Eye Disease.

Zha Z ，Xiao D ，Liu Z ，Peng F ，Shang X ，Sun Z ，Liu Y ，Chen W ... -  《-》

[Huangqin Decoction alleviates ulcerative colitis in mice by reducing endoplasmic reticulum stress].

Qiu J ，Qiu Y ，Li G ，Zhang L ，Zheng X ，Yao Y ，Wang X ，Huang H ，Zhang F ，Su J ，Zheng X ，Huang X ... -  《-》