Molecular Biology of Pituitary Adenomas.

Pituitary adenomas are benign tumors, but still cause significant morbidity and in some cases increases in mortality. Surgical resection is not without risks, and approximately 40% of adenomas are incompletely resected. Medical therapies such as dopamine agonists, somatostatin analogues, and growth hormone antagonists are associated with numerous side effects. Understanding the molecular biology of pituitary adenomas may yield new therapeutic approaches. Additional studies are needed to help determine which genes or pathways are "drivers" of tumorigenesis and should be therapeutic targets. Further studies may also enable pituitary adenoma stratification to tailor treatment approaches.

Faltermeier CM ，Magill ST ，Blevins LS Jr ，Aghi MK ... -  《-》

Functional characterization of DLK1/MEG3 locus on chromosome 14q32.2 reveals the differentiation of pituitary neuroendocrine tumors.

Chen Y ，Gao H ，Liu Q ，Xie W ，Li B ，Cheng S ，Guo J ，Fang Q ，Zhu H ，Wang Z ，Wang J ，Li C ，Zhang Y ... -  《Aging-US》

Lineage-dependent role of miR-410-3p as oncomiR in gonadotroph and corticotroph pituitary adenomas or tumor suppressor miR in somatotroph adenomas via MAPK, PTEN/AKT, and STAT3 signaling pathways.

Grzywa TM ，Klicka K ，Rak B ，Mehlich D ，Garbicz F ，Zieliński G ，Maksymowicz M ，Sajjad E ，Włodarski PK ... -  《-》

Hepatocyte growth factor-regulated tyrosine kinase substrate (HGS) and guanylate kinase 1 (GUK1) are differentially expressed in GH-secreting adenomas.

da Rocha AA ，Giorgi RR ，de Sa SV ，Correa-Giannella ML ，Fortes MA ，Cavaleiro AM ，Machado MC ，Cescato VA ，Bronstein MD ，Giannella-Neto D ... -  《Pituitary》

Patterns of gene expression in pituitary carcinomas and adenomas analyzed by high-density oligonucleotide arrays, reverse transcriptase-quantitative PCR, and protein expression.

Ruebel KH ，Leontovich AA ，Jin L ，Stilling GA ，Zhang H ，Qian X ，Nakamura N ，Scheithauer BW ，Kovacs K ，Lloyd RV ... -  《ENDOCRINE》