Ischaemic heart disease and stroke mortality by specific coal type among non-smoking women with substantial indoor air pollution exposure in China.

Lifetime use of bituminous ('smoky') coal is associated with nearly a 100-fold higher risk of lung cancer mortality compared with anthracite ('smokeless') coal use in rural Xuanwei, China, among women. Risk of mortality from ischaemic heart disease (IHD) and stroke for these coal types has not been evaluated. A cohort of 16 323 non-smoking women in Xuanwei, who were lifetime users of either smoky or smokeless coal, were followed up from 1976 to 2011. We estimated hazard ratios (HRs) and 95% confidence intervals (CI) to evaluate lifetime use of coal types and stoves in the home in relation to risk of IHD and stroke mortality. Among lifetime users of smokeless coal, higher average exposure intensity (≥4 tons/year vs <2.5 tons/year, HR = 7.9, 95% CI = 3.5-17.8; Ptrend =<0.0001) and cumulative exposure (>64 ton-years vs ≤28 ton-years, HR = 6.5, 95% CI = 1.5-28.3; Ptrend =0.003) during follow-up and over their lifetime was associated with increased IHD mortality, and ventilated stove use dramatically reduced this risk (HR = 0.2, 95% CI 0.1-0.5). Higher cumulative exposure to smoky coal during follow-up showed positive associations with IHD mortality, but the evidence for other metrics was less consistent compared with associations with smokeless coal use. Higher use of smokeless coal, which is burned throughout China and is generally regarded to be a cleaner fuel type, is associated with IHD mortality. Use of cleaner fuels or stove interventions may be effective in reducing the increasing burden of IHD in developing regions that currently rely on smokeless coal for cooking and heating.

Bassig BA ，Dean Hosgood H ，Shu XO ，Vermeulen R ，Chen BE ，Katki HA ，Seow WJ ，Hu W ，Portengen L ，Ji BT ，Wong JYY ，Ning B ，Downward GS ，Li J ，Yang K ，Yang G ，Gao YT ，Xiang YB ，Nagaradona T ，Zheng W ，Silverman DT ，Huang Y ，Lan Q ... -  《-》

Overall and cause-specific mortality rates among men and women with high exposure to indoor air pollution from the use of smoky and smokeless coal: a cohort study in Xuanwei, China.

Never-smoking women in Xuanwei (XW), China, have some of the highest lung cancer rates in the country. This has been attributed to the combustion of smoky coal used for indoor cooking and heating. The aim of this study was to evaluate the spectrum of cause-specific mortality in this unique population, including among those who use smokeless coal, considered 'cleaner' coal in XW, as this has not been well-characterised. Cohort study. XW, a rural region of China where residents routinely burn coal for indoor cooking and heating. Age-adjusted, cause-specific mortality rates between 1976 and 2011 were calculated and compared among lifetime smoky and smokeless coal users in a cohort of 42 420 men and women from XW. Mortality rates for XW women were compared with those for a cohort of predominately never-smoking women in Shanghai. Mortality in smoky coal users was driven by cancer (41%), with lung cancer accounting for 88% of cancer deaths. In contrast, cardiovascular disease (CVD) accounted for 32% of deaths among smokeless coal users, with 7% of deaths from cancer. Total cancer mortality was four times higher among smoky coal users relative to smokeless coal users, particularly for lung cancer (standardised rate ratio (SRR)=17.6). Smokeless coal users had higher mortality rates of CVD (SRR=2.9) and pneumonia (SRR=2.5) compared with smoky coal users. These patterns were similar in men and women, even though XW women rarely smoked cigarettes. Women in XW, regardless of coal type used, had over a threefold higher rate of overall mortality, and most cause-specific outcomes were elevated compared with women in Shanghai. Cause-specific mortality burden differs in XW based on the lifetime use of different coal types. These observations provide evidence that eliminating all coal use for indoor cooking and heating is an important next step in improving public health particularly in developing countries.

Nagaradona T ，Bassig BA ，Hosgood D ，Vermeulen RCH ，Ning B ，Seow WJ ，Hu W ，Portengen L ，Wong J ，Shu XO ，Zheng W ，Appel N ，Gao YT ，Cai QY ，Yang G ，Chen Y ，Downward G ，Li J ，Yang K ，McCullough L ，Silverman D ，Huang Y ，Lan Q ... -  《BMJ Open》

Risk of lung cancer associated with domestic use of coal in Xuanwei, China: retrospective cohort study.

Barone-Adesi F ，Chapman RS ，Silverman DT ，He X ，Hu W ，Vermeulen R ，Ning B ，Fraumeni JF Jr ，Rothman N ，Lan Q ... -  《BMJ-British Medical Journal》

Household air pollution and lung cancer in China: a review of studies in Xuanwei.

Seow WJ ，Hu W ，Vermeulen R ，Hosgood Iii HD ，Downward GS ，Chapman RS ，He X ，Bassig BA ，Kim C ，Wen C ，Rothman N ，Lan Q ... -  《-》

Portable stove use is associated with lower lung cancer mortality risk in lifetime smoky coal users.

Hosgood HD 3rd ，Chapman R ，Shen M ，Blair A ，Chen E ，Zheng T ，Lee KM ，He X ，Lan Q ... -  《-》