Solid self-microemulsifying drug delivery system of Sophoraflavanone G: Prescription optimization and pharmacokinetic evaluation.

Sophoraflavanone G (SFG) is promising component in clinical treatment. The purpose of this study was to develop a drug delivery system in order to improve oral bioavailability of SFG. The optimum formulation of Self-microemulsifying Drug Delivery System with SFG (SFG-SMEDDS) was selected by the solubility test, self-emulsifying grading test and ternary phase diagram test. The optimized formulation of SFG-S-SMEDDS was composed of Ethyl Oleate (38.5%, w/w), Cremophor RH40 (47.5%, w/w), PEG 400 (14.0%, w/w), and drug loading (20 mg/g). Mannitol as a solid absorbent was added to SFG-SMEDDS formulation with the mass adsorption ratio of 2:1 (w/w). The vitro release rate of SFG-S-SMEDDS reached 60% in 10 min and 80% in 30 min. After SD rats were given SFG and SFG-S-SMEDDS by oral administration, it was found that the area under the curve of SFG-S-SMEDDS was significantly larger than that of SFG suspension and the relative bioavailability of SFG in rats was 343.84%. In addition, the SFG-S-SMEDDS did not change greatly within 3 months. Therefore, the results show that SFG-S-SMEDDS can significantly improve the oral bioavailability of SFG so as to lay a foundation of further research on the new dosage form of SFG.

Yang Z ，Wang Y ，Cheng J ，Shan B ，Wang Y ，Wang R ，Hou L ... -  《-》

Preparation and evaluation of valsartan by a novel semi-solid self-microemulsifying delivery system using Gelucire 44/14.

Zhao K ，Yuan Y ，Wang H ，Li P ，Bao Z ，Li Y ... -  《-》

Preparation and Pharmacokinetics Evaluation of Solid Self-Microemulsifying Drug Delivery System (S-SMEDDS) of Osthole.

Sun C ，Gui Y ，Hu R ，Chen J ，Wang B ，Guo Y ，Lu W ，Nie X ，Shen Q ，Gao S ，Fang W ... -  《AAPS PHARMSCITECH》

Anti-hyperuricemic property of 6-shogaol via self-micro emulsifying drug delivery system in model rats: formulation design, in vitro and in vivo evaluation.

Yang Q ，Wang Q ，Feng Y ，Wei Q ，Sun C ，Firempong CK ，Adu-Frimpong M ，Li R ，Bao R ，Toreniyazov E ，Ji H ，Yu J ，Xu X ... -  《-》

Improved oral bioavailability of poorly water-soluble indirubin by a supersaturatable self-microemulsifying drug delivery system.

Chen ZQ ，Liu Y ，Zhao JH ，Wang L ，Feng NP ... -  《International Journal of Nanomedicine》