Mesenchymal Stem Cell (MSC)-Derived Extracellular Vesicles: Potential Therapeutics as MSC Trophic Mediators in Regenerative Medicine.

Mesenchymal stem cells (MSCs) are pluripotent progenitor cells with the capabilities of self-renewing, differentiating into multiple lineages, and achieving trophic effects during tissue repair. MSCs can secrete extracellular vesicles (EVs) including exosomes and microvesicles, which mediate their trophic effects on other cells. Carrying a variety of intracellular molecules of MSCs including lipids, proteins, RNA (mRNA and noncoding RNA), and DNA, EVs deliver them into other cells to regulate tissue regeneration process. The therapeutic effects of MSC-derived EVs have been observed in a number of animal disease models. In this review, we focus on the current state and future directions of MSC-derived EVs in regenerative medicine. Anat Rec, 2019. © 2019 Wiley Periodicals, Inc.

Yuan QL ，Zhang YG ，Chen Q 《-》

Mesenchymal Stem Cell-Derived Extracellular Vesicles in Tissue Regeneration.

Zhang B ，Tian X ，Hao J ，Xu G ，Zhang W ... -  《-》

Mesenchymal stem cell-derived extracellular vesicles: novel frontiers in regenerative medicine.

Keshtkar S ，Azarpira N ，Ghahremani MH 《Stem Cell Research & Therapy》

Perspectives for Future Use of Extracellular Vesicles from Umbilical Cord- and Adipose Tissue-Derived Mesenchymal Stem/Stromal Cells in Regenerative Therapies-Synthetic Review.

Lelek J ，Zuba-Surma EK 《INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES》

Regenerative Potential of Mesenchymal Stem Cell-Derived Extracellular Vesicles.

Mesenchymal stem cells (MSCs) are multipotent cells that can differentiate into diverse cell lineages. MSC based therapy has become a widely experimented treatment strategy in regenerative medicine with promising outcomes. Recent reports suggest that much of the therapeutic effects of MSCs are mediated by their secretome that is expressed through extracellular vesicles (EVs). EVs are lipid bilayer bound components that carry cellular proteins, mRNA, lncRNAs, and other molecules in order to mediate intercellular communication and signaling. In fact, MSC-derived EVs have been observed to implement the same therapeutic effects as MSCs with minimal adverse effects and could be used as an alternative treatment method to MSC-based therapy. The regenerative activity of MSC-EVs has been observed in relation to multiple cell/tissue lineages using various animal models. However, further research and clinical trials are essential for the advancement of this novel treatment strategy. This review provides an insight into the available literature on applications of MSC-EVs in relation to angiogenesis, neurogenesis, hepatic and kidney regeneration, and wound healing.

Thalakiriyawa DS ，Jayasooriya PR ，Dissanayaka WL 《-》