Modulatory effects of curcumin on heat shock proteins in cancer: A promising therapeutic approach.

Cancer metastasis represents a multistep process, including alteration of cell adhesion/motility in the microenvironment and sustained angiogenesis, which is essential for supporting cancer growth in tissues that are distant from the primary tumor. There is growing evidence suggesting that heat shock proteins (HSPs) (also known as heat stress proteins), which constitute a family of stress-inducible proteins, may be involved in the pathogenesis of cancer. Curcumin (diferuloylmethane) is a potent anti-inflammatory, antioxidant, antimicrobial, and antitumor agent. Curcumin has been shown to regulate different members of HSPs including HSP27, HSP40, HSP60, HSP70, and HSP90 in cancer. Here, we present extent findings suggesting that curcumin may act as a potential therapeutic agent for the treatment of cancer through its regulation of HSPs.

Forouzanfar F ，Barreto G ，Majeed M ，Sahebkar A ... -  《-》

Expression of heat shock proteins in medulloblastoma.

Alexiou GA ，Vartholomatos G ，Stefanaki K ，Patereli A ，Dova L ，Karamoutsios A ，Lallas G ，Sfakianos G ，Moschovi M ，Prodromou N ... -  《-》

Heat Shock Proteins Promote Cancer: It's a Protection Racket.

Heat shock proteins (HSP) are expressed at high levels in cancer and form a fostering environment that is essential for tumor development. Here, we review the recent data in this area, concentrating mainly on Hsp27, Hsp70, and Hsp90. The overriding role of HSPs in cancer is to stabilize the active functions of overexpressed and mutated cancer genes. Thus, elevated HSPs are required for many of the traits that underlie the morbidity of cancer, including increased growth, survival, and formation of secondary cancers. In addition, HSPs participate in the evolution of cancer treatment resistance. HSPs are also released from cancer cells and influence malignant properties by receptor-mediated signaling. Current data strongly support efforts to target HSPs in cancer treatment.

Calderwood SK ，Gong J 《TRENDS IN BIOCHEMICAL SCIENCES》

Heat shock proteins in cancer stem cell maintenance: A potential therapeutic target?

Lettini G ，Lepore S ，Crispo F ，Sisinni L ，Esposito F ，Landriscina M ... -  《-》

Expression of heat shock proteins (HSP27, HSP60, HSP70, HSP90, GRP78, GRP94) in hepatitis B virus-related hepatocellular carcinomas and dysplastic nodules.

Lim SO ，Park SG ，Yoo JH ，Park YM ，Kim HJ ，Jang KT ，Cho JW ，Yoo BC ，Jung GH ，Park CK ... -  《-》