Short interpregnancy intervals and adverse pregnancy outcomes by maternal age in the United States.

The purpose of the article was to examine the association between short interpregnancy intervals and adverse outcomes by maternal age among U.S. women. Using publicly available natality files for 2013-2016 singleton births, we compared the risks of preterm birth, gestational diabetes, gestational hypertension, and maternal morbidity (delivery-related complications) for less than 6-month, 6 to 11-month, and 12 to 17-month to 18- to 23-month interpregnancy intervals, overall and by maternal age. Models adjusted for maternal demographics, conditions, and behaviors. Among 2,365,219 births, adjusted risk ratios (aRR) for preterm birth overall for intervals less than 6, 6-11, and 12-17 months were 1.62 (95% confidence interval: 1.60, 1.65), 1.16 (1.15, 1.18), and 1.03 (1.02, 1.05), respectively, compared with 18-23 months. Intervals less than 6, 6-11, and 12-17 months were significantly protective overall for gestational diabetes (aRR range: 0.89-0.98), gestational hypertension (aRR range: 0.93-0.95), and maternal morbidity (aRR range: 0.93-1.08). All aRRs attenuated or remained flat with increasing maternal age. Interpregnancy intervals less than 18 months showed different patterns of association for preterm birth compared with maternal outcomes, overall and across age. This suggests that increasing maternal age may have discordant effects on associations between short interpregnancy interval and adverse perinatal and maternal outcomes.

Haight SC ，Hogue CJ ，Raskind-Hood CL ，Ahrens KA ... -  《-》

Association of Short Interpregnancy Interval With Pregnancy Outcomes According to Maternal Age.

Schummers L ，Hutcheon JA ，Hernandez-Diaz S ，Williams PL ，Hacker MR ，VanderWeele TJ ，Norman WV ... -  《-》

Interpregnancy Interval and Adverse Pregnancy Outcomes: An Analysis of Successive Pregnancies.

Hanley GE ，Hutcheon JA ，Kinniburgh BA ，Lee L ... -  《-》

Short interpregnancy interval and adverse birth outcomes in women of advanced age: a population-based study.

Short interpregnancy interval (IPI) has been linked with adverse birth outcomes. However, the association in advanced age women needs further investigation. This study aims to examine the association between short IPI and adverse birth outcomes including preterm birth, post-term birth, low birth weight, and macrosomia, in a population of advanced age U.S. women. The 2016 U.S. public-use natality data was analyzed. Analysis was restricted to women with second-order singleton live births who were ≥35 years at first live birth (n = 46,684). Multinomial logistic regression analysis was used to examine the association between short IPI and adverse birth outcomes. Short IPI in advanced age women was significantly associated with higher odds of extremely preterm birth (0-5 months IPI: adjusted odds ratio [AOR] = 2.43, 95% confidence interval [CI] = 1.07-5.52; 6-11 months IPI: AOR = 2.17, 95% CI = 1.09-4.31), very preterm birth (0-5 months IPI: AOR = 1.63, 95% CI = 1.04-2.56), and extremely low birth weight (0-5 months IPI: AOR = 2.43, 95% CI = 1.28-4.60) in the second delivery. An inverse relationship between short IPI and post-term birth was observed and no significant association between short IPI and macrosomia was found. Short IPI in advanced age women increases the odds of adverse birth outcomes in the second delivery.

Ihongbe TO ，Wallenborn JT ，Rozario S ，Masho SW ... -  《-》

Within-Family Analysis of Interpregnancy Interval and Adverse Birth Outcomes.

Class QA ，Rickert ME ，Oberg AS ，Sujan AC ，Almqvist C ，Larsson H ，Lichtenstein P ，D'Onofrio BM ... -  《-》