Recurrence of periocular basal cell carcinoma and squamous cell carcinoma after Mohs micrographic surgery: a retrospective cohort study.

Despite the widespread use of Mohs micrographic surgery (MMS) for periocular basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) - together called keratinocyte carcinoma (KC) - follow-up data regarding recurrences are limited. To investigate the recurrence rate for periocular KCs after MMS and to describe our experience with interdisciplinary collaborations. Patients with periocular KCs treated with MMS between 2006 and 2016 in a tertiary MMS referral hospital were included in this retrospective cohort study. Descriptive statistics were used to describe the MMS procedure-related characteristics. Using follow-up data from the electronic patient records and linkage with the Dutch nationwide network and registry of histopathology and cytopathology on 30 June 2017, the recurrence rate was evaluated and calculated using a cumulative incidence curve. In total, 683 (93·7%) periocular BCCs and 46 (6·3%) SCCs were treated with MMS. Three-quarters (n = 549) were primary tumours and the majority were located at the medial canthus or lower eyelid (n = 649, 89·0%). In 505 MMS procedures (69·3%) an oculoplastic surgeon participated, and in 63 patients (8·6%) a plastic surgeon performed the reconstruction. After a median follow-up of 46 months the recurrence rate was 3·0%, based on 22 recurrences (20 BCCs and two SCCs). MMS is an excellent treatment option for periocular KCs, with a low recurrence rate. Due to this specific anatomical location an interdisciplinary approach should pre-eminently be considered.

Weesie F ，Naus NC ，Vasilic D ，Hollestein LM ，van den Bos RR ，Wakkee M ... -  《-》

Management of periocular keratinocyte carcinomas with Mohs micrographic surgery and predictors of complex reconstruction: a retrospective study.

Skin cancer is the most frequent cancer worldwide and the most frequent periocular tumor. Keratinocyte Carcinomas (KC) located in periorificial areas, such as periocular tumors, are considered high-risk tumors. Mohs Micrographic Surgery (MMS) is considered the first line for the treatment of high-risk KC, providing a lower recurrence rate than conventional wide excision. To describe the clinical-pathological features of periocular KC treated with MMS in a tertiary university center in Chile. A single-center, retrospective study of patients with KC located on the periocular area, that underwent MMS between 2017‒2022. MMS details were recorded. One hundred thirteen patients with periocular carcinomas were included. The mean age was 59 ± 13 years; 52% were women. The most frequent location was the medial canthus (53%), followed by the lower eyelid (30.1%). The most frequent BCC histology was the nodular variant (59.3%). Regarding MMS, the average number of stages was 1.5 ± 0.7, and 54% of the cases required only 1 stage to achieve clear margins. To date, no recurrence has been reported. Tumors larger than 8.5 mm in largest diameter or 43.5 mm2 were more likely to require complex reconstruction. Retrospective design and a relatively low number of patients in the SCC group. Possible selection bias, as larger or more complex cases, may have been referred to oculoplastic surgeons directly. The present study confirms the role of MMS for the treatment of periocular KCs. Periocular KCs larger than 8.5 mm might require complex reconstruction. These results can be used to counsel patients during pre-surgical visits.

Peirano D ，Vargas S ，Hidalgo L ，Donoso F ，Abusleme E ，Sanhueza F ，Cárdenas C ，Droppelmann K ，Castro JC ，Uribe P ，Zoroquiain P ，Navarrete-Dechent C ... -  《-》

Outcomes of Mohs micrographic surgery for periocular squamous cell carcinoma.

Hartley MJ ，Meredith PR ，Oliphant T 《-》

Management of periocular basal and squamous cell carcinoma: a series of 485 cases.

Nemet AY ，Deckel Y ，Martin PA ，Kourt G ，Chilov M ，Sharma V ，Benger R ... -  《AMERICAN JOURNAL OF OPHTHALMOLOGY》

Recurrence rates of periocular basal cell carcinoma following Mohs micrographic surgery: a retrospective study.

The incidence of basal cell carcinoma (BCC) has increased during the previous decade. Mohs micrographic surgery (MMS) is the gold standard technique for BCCs. The aim of this study was to investigate the recurrence rate of periocular BCCs following MMS in a regional Mohs treatment facility in the United Kingdom. The study comprised a retrospective case note review of 480 patients who underwent MMS from 2001 to 2006 for periocular BCC. Patients were identified via hospital coding databases. Medical records were reviewed, and the parameters collected include age, gender, previous BCCs and treatment modality, postoperative complications and subsequent management, site, size of lesion, histological subtype, and recurrence following MMS. Three hundred and ninety of the 480 patients identified were included. The remaining patients had died before the 5-year analysis (65), were lost to follow-up (20), or were identified as having Gorlin's syndrome (5). The majority of BCCs were 6-10 mm (42%) and nodular (45%). Six recurrences were identified (1.5%), including one (0.3%) primary BCC and five (6.5%) recurrent BCCs at the time of the MMS. The mean follow-up was 30 months (range 1-120 months). For BCC in the periocular region, MMS should be the treatment of choice for both primary and recurrent periocular BCCs. The increased recurrence rate, demonstrated by recurrent BCCs, highlights the need for a comprehensive follow-up.

Sin CW ，Barua A ，Cook A 《-》