Recent progress in the emerging role of exosome in hepatocellular carcinoma.

Exosomes are small membrane vesicles 50-150 nm in diameter released by a variety of cells, which contain miRNAs, mRNAs and proteins with the potential to regulate signalling pathways in recipient cells. Exosomes deliver nucleic acids and proteins to participate in orchestrating cell-cell communication and microenvironment modulation. In this review, we summarize recent progress in our understanding of the role of exosomes in hepatocellular carcinoma (HCC). This review focuses on recent studies on HCC exosomes, considering biogenesis, cargo and their effects on the development and progression of HCC, including chemoresistance, epithelial-mesenchymal transition, angiogenesis, metastasis and immune response. Finally, we discuss the clinical application of exosomes as a therapeutic agent for HCC.

Abudoureyimu M ，Zhou H ，Zhi Y ，Wang T ，Feng B ，Wang R ，Chu X ... -  《-》

Exosome-mediated communication in the tumor microenvironment contributes to hepatocellular carcinoma development and progression.

Wu Q ，Zhou L ，Lv D ，Zhu X ，Tang H ... -  《Journal of Hematology & Oncology》

Role of exosomes and exosomal microRNAs in hepatocellular carcinoma: Potential in diagnosis and antitumour treatments (Review).

Pan JH ，Zhou H ，Zhao XX ，Ding H ，Li W ，Qin L ，Pan YL ... -  《-》

HCC-derived exosomes elicit HCC progression and recurrence by epithelial-mesenchymal transition through MAPK/ERK signalling pathway.

Chen L ，Guo P ，He Y ，Chen Z ，Chen L ，Luo Y ，Qi L ，Liu Y ，Wu Q ，Cui Y ，Fang F ，Zhang X ，Song T ，Guo H ... -  《Cell Death & Disease》

The functional role of exosome in hepatocellular carcinoma.

Liu H ，Li B 《-》