[Even the Warburg effect can be oxidized: metabolic cooperation and tumor development].

During tumor development, malignant cells rewire their metabolism to meet the biosynthetic needs required to increase their biomass and to overcome their microenvironment constraints. The sustained activation of aerobic glycolysis, also called Warburg effect, is one of these adaptative mechanisms. The progresses in this area of research have revealed the flexibility of cancer cells that alternate between glycolytic and oxidative metabolism to cope with their conditions of development while sharing their energetic resources. In this survey, we review these recent breakthroughs and discuss a model that likens tumor to an evolutive metabolic ecosystem. We further emphasize the ensuing therapeutic applications that target metabolic weaknesses of neoplastic cells.

Cordier-Bussat M ，Thibert C ，Sujobert P ，Genestier L ，Fontaine É ，Billaud M ... -  《-》

Metabolic reprogramming: the emerging concept and associated therapeutic strategies.

Yoshida GJ 《JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH》

Cancer proliferation and therapy: the Warburg effect and quantum metabolism.

Demetrius LA ，Coy JF ，Tuszynski JA 《Theoretical Biology and Medical Modelling》

Linking tumor glycolysis and immune evasion in cancer: Emerging concepts and therapeutic opportunities.

Metabolic reprogramming and immune evasion are two hallmarks of cancer. Metabolic reprogramming is exemplified by cancer's propensity to utilize glucose at an exponential rate which in turn is linked with "aerobic glycolysis", popularly known as the "Warburg effect". Tumor glycolysis is pivotal for the efficient management of cellular bioenergetics and uninterrupted cancer growth. Mounting evidence suggests that tumor glycolysis also plays a key role in instigating immunosuppressive networks that are critical for cancer cells to escape immune surveillance ("immune evasion"). Recent data show that induction of cellular stress or metabolic dysregulation sensitize cancer cells to antitumor immune cells implying that metabolic reprogramming and immune evasion harmonize during cancer progression. However, the molecular link between these two hallmarks of cancer remains obscure. In this review the molecular intricacies of tumor glycolysis that facilitate immune evasion has been discussed in the light of recent research to explore immunotherapeutic potential of targeting cancer metabolism.

Ganapathy-Kanniappan S 《BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER》

Mitochondria in cancer: not just innocent bystanders.

Frezza C ，Gottlieb E 《-》