ST2 and left ventricular remodeling after ST-segment elevation myocardial infarction: A cardiac magnetic resonance study.

The association of soluble interleukin-1 receptor-like 1 (ST2) with left ventricular (LV) remodeling is unclear in patients with a first ST-segment elevation myocardial infarction (STEMI). The objective of this work was to assess the relationship between ST2, a marker of inflammation, and cardiac magnetic resonance (CMR) imaging-derived LV remodeling after a first STEMI. We prospectively evaluated 109 patients with a first STEMI treated with primary percutaneous coronary intervention who had ST2 assessed 24 h post-reperfusion. All patients underwent CMR imaging 1 week and 6 months after STEMI. The independent associations between ST2, LV diastolic and systolic volume indices, and LV ejection fraction (LVEF) were evaluated by linear mixed models. The mean age of the sample was 59 ± 12 years, 85 patients (78%) were male, and 13 (11.9%) had a LVEF ≤40%. The median (IQR) of ST2 was 55.3 (38.7-94.1) pg/mL. At 1-week CMR higher ST2 was related to more infarct size and less myocardial salvage index (p < 0.01). Overall, after comprehensive multivariable adjustment, higher baseline ST2 was associated with progressive LV volume indices dilation and LVEF deterioration (p < 0.05). This effect was stronger in patients with severe 1-week structural damage, namely those with large infarct size, extensive microvascular obstruction or LVEF ≤40%. In patients with a first STEMI treated with primary percutaneous coronary intervention, soluble ST2 predicts dynamic changes in CMR-derived LV volumes and LVEF. Future studies must assess whether targeting interleukin-1 leads to lower ST2 levels and less LV remodeling.

Miñana G ，Núñez J ，Bayés-Genís A ，Revuelta-López E ，Ríos-Navarro C ，Núñez E ，Chorro FJ ，López-Lereu MP ，Monmeneu JV ，Lupón J ，Bodí V ... -  《-》

Global longitudinal strain by feature tracking for optimized prediction of adverse remodeling after ST-elevation myocardial infarction.

Reindl M ，Tiller C ，Holzknecht M ，Lechner I ，Eisner D ，Riepl L ，Pamminger M ，Henninger B ，Mayr A ，Schwaiger JP ，Klug G ，Bauer A ，Metzler B ，Reinstadler SJ ... -  《-》

[Predictive value of cardiac magnetic resonance imaging for adverse left ventricular remodeling after acute ST-segment elevation myocardial infarction].

Cui J ，Liu W ，Yan F ，Zhao Y ，Chen W ，Luo C ，Zhang X ，Li T ... -  《-》

Defining left ventricular remodeling following acute ST-segment elevation myocardial infarction using cardiovascular magnetic resonance.

Bulluck H ，Go YY ，Crimi G ，Ludman AJ ，Rosmini S ，Abdel-Gadir A ，Bhuva AN ，Treibel TA ，Fontana M ，Pica S ，Raineri C ，Sirker A ，Herrey AS ，Manisty C ，Groves A ，Moon JC ，Hausenloy DJ ... -  《-》

Left Ventricular Hypertrophy Is Associated With Increased Infarct Size and Decreased Myocardial Salvage in Patients With ST-Segment Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention.

Approximately one third of patients with ST-segment elevation myocardial infarction (STEMI) have left ventricular hypertrophy (LVH), which is associated with impaired outcome. However, the causal association between LVH and outcome in STEMI is unknown. We evaluated the association between LVH and: myocardial infarct size, area at risk, myocardial salvage, microvascular obstruction, left ventricular (LV) function (all determined by cardiac magnetic resonance [CMR]), and all-cause mortality and readmission for heart failure in STEMI patients treated with primary percutaneous coronary intervention. In this substudy of the DANAMI-3 trial, 764 patients underwent CMR. LVH was defined by CMR and considered present if LV mass exceeded 77 (men) and 67 g/m2 (women). One hundred seventy-eight patients (24%) had LVH. LVH was associated with a larger final infarct size (15% [interquartile range {IQR}, 10-21] vs 9% [IQR, 3-17]; P<0.001) and smaller final myocardial salvage index (0.6 [IQR, 0.5-0.7] vs 0.7 [IQR, 0.5-0.9]; P<0.001). The LVH group had a higher incidence of microvascular obstruction (66% vs 45%; P<0.001) and lower final LV ejection fraction (LVEF; 53% [IQR, 47-60] vs 61% [IQR, 55-65]; P<0.001). In a Cox regression analysis, LVH was associated with a higher risk of all-cause mortality and readmission for heart failure (hazard ratio 2.59 [95% CI, 1.38-4.90], P=0.003). The results remained statistically significant in multivariable models. LVH is independently associated with larger infarct size, less myocardial salvage, higher incidence of microvascular obstruction, lower LVEF, and a higher risk of all-cause mortality and incidence of heart failure in STEMI patients treated with primary percutaneous coronary intervention. URL: http://www.clinicaltrials.gov. Unique identifier: NCT01435408.

Nepper-Christensen L ，Lønborg J ，Ahtarovski KA ，Høfsten DE ，Kyhl K ，Ghotbi AA ，Schoos MM ，Göransson C ，Bertelsen L ，Køber L ，Helqvist S ，Pedersen F ，Saünamaki K ，Jørgensen E ，Kelbæk H ，Holmvang L ，Vejlstrup N ，Engstrøm T ... -  《Journal of the American Heart Association》