MiR-214 promotes cell meastasis and inhibites apoptosis of esophageal squamous cell carcinoma via PI3K/AKT/mTOR signaling pathway.

There is growing evidence shown that microRNAs (miRNAs) are associated with cancer and can play a role in human cancers as oncogenes or tumor suppressor genes. MicroRNA-214 (miR-214) shows carcinogenesis in various tumor types, but little is known about biological functions of miR-214 in esophageal squamous cell carcinoma (ESCC). In this study, we observe that the expression of miR-214 is not only increased in human ESCC tissues, but also remarkably increased in cell lines correlates with LZTS1. In addition, the expression of miR-214 inhibited proliferation of ESCC cells in vitro and inhibit the growth of xenograft tumor in vivo. The results show miR-214 serve as a tumor promoter regulating cells migration, invasion and apoptosis in ESCC. Ferthermore, LZTS1 has been proved to as a functional target for miR-214 to regulate cells poliferation and apoptosis. In summary, these results suggest that miR-214 serves as tumor promoter to promote proliferation, migration, invasion and inhibit apoptosis of ESCC cells by targeting LZTS1 via PI3K/AKT/mTOR signaling pathway. The miR-214/LZTS1 pathway provides a new insight into the molecular mechanisms that the occurrence and development of ESCC and it provides a novel therapeutic target for ESCC.

Guanen Q ，Junjie S ，Baolin W ，Chaoyang W ，Yajuan Y ，Jing L ，Junpeng L ，Gaili N ，Zhongping W ，Jun W ... -  《-》

Upregulation of miR-519 enhances radiosensitivity of esophageal squamous cell carcinoma trough targeting PI3K/AKT/mTOR signaling pathway.

Zhang Y ，Chen W ，Wang H ，Pan T ，Zhang Y ，Li C ... -  《-》

Downregulation of MiR-31 stimulates expression of LATS2 via the hippo pathway and promotes epithelial-mesenchymal transition in esophageal squamous cell carcinoma.

Gao Y ，Yi J ，Zhang K ，Bai F ，Feng B ，Wang R ，Chu X ，Chen L ，Song H ... -  《JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH》

MicroRNA-126 is down-regulated in human esophageal squamous cell carcinoma and inhibits the proliferation and migration in EC109 cell via PI3K/AKT signaling pathway.

Nie ZC ，Weng WH ，Shang YS ，Long Y ，Li J ，Xu YT ，Li Z ... -  《International Journal of Clinical and Experimental Pathology》

miR-1 suppresses the growth of esophageal squamous cell carcinoma in vivo and in vitro through the downregulation of MET, cyclin D1 and CDK4 expression.

Jiang S ，Zhao C ，Yang X ，Li X ，Pan Q ，Huang H ，Wen X ，Shan H ，Li Q ，Du Y ，Zhao Y ... -  《-》