Preoperative serum ST2 level predicts acute kidney injury after adult cardiac surgery.

The purpose of this study was to evaluate the relationship between preoperative levels of serum soluble ST2 (ST2) and acute kidney injury (AKI) after cardiac surgery. Previous research has shown that biomarkers facilitate the prediction of AKI and other complications after cardiac surgery. Preoperative ST2 proteins were measured in 1498 patients undergoing isolated coronary artery bypass graft surgery at 8 hospitals participating in the Northern New England Biomarker Study from 2004 to 2007. AKI severity was defined using the Acute Kidney Injury Network (AKIN) definition. Preoperative ST2 levels were measured using multiplex assays. Ordered logistic regression was used to examine the relationship between ST2 levels and levels of AKI severity. Participants in this study showed a significant association between elevated preoperative ST2 levels and acute kidney risk. Before adjustment, the odds of patients developing AKIN stage 2 or 3, compared with AKIN stage 1, are 2.43 times higher (95% confidence interval, 1.86-3.16; P < .001) for patients in the highest tercile of preoperative ST2. After adjustment, patients in the highest tercile of preoperative ST2 had significantly greater odds of developing AKIN stage 2 or 3 AKI (odds ratio, 1.99; 95% confidence interval, 1.50-2.65; P < .001) compared with patients with AKIN stage 1. Preoperative ST2 levels are associated with postoperative AKI risk and can be used to identify patients at higher risk of developing AKI after cardiac surgery.

Lobdell KW ，Parker DM ，Likosky DS ，Rezaee M ，Wyler von Ballmoos M ，Alam SS ，Owens S ，Thiessen-Philbrook H ，MacKenzie T ，Brown JR ... -  《-》

Elevated preoperative Galectin-3 is associated with acute kidney injury after cardiac surgery.

Wyler von Ballmoos M ，Likosky DS ，Rezaee M ，Lobdell K ，Alam S ，Parker D ，Owens S ，Thiessen-Philbrook H ，MacKenzie T ，Brown JR ... -  《-》

Predictive Value of Serum Soluble ST2 in Adult Patients Undergoing Cardiac Surgery for Acute Kidney Injury.

Cardiac surgery is related to an increased risk of postoperative acute kidney injury (AKI). Serum soluble ST2 (sST2) is highly predictive of several cardiovascular diseases and may also be involved in renal injury. This study explored the relationship between serum sST2 levels measured at intensive care unit (ICU) admission and the development of AKI after cardiac surgery. We prospectively conducted an investigation on consecutive patients who underwent cardiac surgery. sST2 was immediately measured at ICU admission. The relationship between the levels of sST2 and the development of AKI was explored using stepwise logistic regression. Among the 500 patients enrolled, AKI was observed in 207 (41%) patients. Serum sST2 levels in AKI patients were higher than those without AKI (61.46 ng/mL [46.52, 116.25] vs. 38.91 ng/mL [28.74, 50.93], p &lt; 0.001). Additionally, multivariable logistic regression analysis showed that as progressively higher tertiles of serum sST2, the odds ratios (ORs) of AKI gradually increased (adjusted ORs of 1.97 [95% CI, 1.13-3.45], and 4.27 [95% CI, 2.36-7.71] for tertiles 2 and 3, respectively, relative to tertile 1, p &lt; 0.05). The addition of sST2 further improved reclassification (p &lt; 0.001) and discrimination (p &lt; 0.001) over the basic model, which included established risk factors. Serum sST2 levels at ICU admission were associated with the development of postoperative AKI and improved the identification of AKI after cardiac surgery.

Chen Z ，Li J ，Liu X ，Liu X ，Zhu J ，Tang X ，Deng Y ，Chen C ... -  《-》

Preoperative serum uric acid predicts incident acute kidney injury following cardiac surgery.

Kaufeld T ，Foerster KA ，Schilling T ，Kielstein JT ，Kaufeld J ，Shrestha M ，Haller HG ，Haverich A ，Schmidt BMW ... -  《BMC Nephrology》

Interleukin-6 and interleukin-10 as acute kidney injury biomarkers in pediatric cardiac surgery.

Greenberg JH ，Whitlock R ，Zhang WR ，Thiessen-Philbrook HR ，Zappitelli M ，Devarajan P ，Eikelboom J ，Kavsak PA ，Devereaux PJ ，Shortt C ，Garg AX ，Parikh CR ，TRIBE-AKI Consortium ... -  《-》