Subsequent nonmelanoma skin cancers and impact of immunosuppression in liver transplant recipients.

Nonmelanoma skin cancers (NMSCs) are the most frequent cancers in solid organ transplant recipients, with a high rate of subsequent tumors. To describe subsequent NMSCs in a large cohort of liver transplant recipients (LTRs) with long follow-up and analyze the factors influencing it, including immunosuppressive regimen. A total of 96 LTRs (76 male) with a personal post-transplant history of squamous cell carcinoma, basal cell carcinoma or Bowen's disease were included, with a median follow-up of 12.4 years (range, 1.5-27.8) after liver transplantation. The median follow-up after first NMSC was 6.4 years (range, 0.17-22.1). In all, 52 patients (53.1%) developed 141 subsequent NMSCs with a basal cell carcinoma-to-squamous cell carcinoma ratio of 1.8:1. The actuarial risk for development of a second NMSC was 13.7% at 1 year, 28.4% at 2 years, 49.4% at 5 years, 65.7% at 10 years, and 88.4% at 15 years. Multivariate analysis found that skin phototype I or II (vs III or IV) was a significant risk factor for development of a second NMSC (hazard ratio, 2.556; 95% confidence interval, 1.45-4.48; P = .001), whereas withdrawal of calcineurin inhibitors was significantly protective (hazard ratio, 0.358; 95% confidence interval, 0.142-0.902; P = .029). Retrospective analysis. Subsequent NMSCs are very frequent in LTRs, and conversion from a calcineurin inhibitor-based immunosuppressive regimen to a mammalian target of rapamycin inhibitor/antimetabolite-based immunosuppressive regimen can reduce subsequent NMSCs.

Funk-Debleds P ，Ducroux E ，Guillaud O ，Ursic-Bedoya J ，Decullier E ，Vallin M ，Euvrard S ，Pageaux GP ，Boillot O ，Dumortier J ... -  《-》

First and subsequent nonmelanoma skin cancers: incidence and predictors in a population of New Zealand renal transplant recipients.

Mackenzie KA ，Wells JE ，Lynn KL ，Simcock JW ，Robinson BA ，Roake JA ，Currie MJ ... -  《-》

Immunosuppressive level and other risk factors for basal cell carcinoma and squamous cell carcinoma in heart transplant recipients.

Fortina AB ，Piaserico S ，Caforio AL ，Abeni D ，Alaibac M ，Angelini A ，Iliceto S ，Peserico A ... -  《ARCHIVES OF DERMATOLOGY》

[Patients with solid organ transplantation and skin cancer: determination of risk factors with emphasis in photoexposure and immunosuppressive regimen. Experience in a third level hospital].

Rodríguez-Acosta ED ，Calva-Mercado JJ ，Alberú-Gómez J ，Vilatoba-Chapa M ，Domínguez-Cherit J ... -  《Gaceta Medica de Mexico》

Nonmelanoma skin cancer after liver transplantation. Study of risk factors.

Herrero JI ，España A ，Quiroga J ，Sangro B ，Pardo F ，Alvárez-Cienfuegos J ，Prieto J ... -  《LIVER TRANSPLANTATION》