Ewing's sarcoma of the maxillofacial region in Greek children: Report of 6 cases and literature review.

The rarity of Ewing's sarcoma (ES) in the maxillofacial region of children, coupled with the technical challenge of resection and associated functional and cosmetic impairment has resulted in deficient data regarding the optimal local control of the disease. To describe our experience in the management of primary maxillofacial ES in children, focusing on the therapeutic modalities for local control of the disease. Single institution observational study. This is a single institution review of patients, treated between 2007 and 2016. Six primary maxillofacial ES were treated according to the EURO-EWING 99 protocol, consisting of a uniform chemotherapy regimen, combined selectively with surgery and radiotherapy as local treatment. Patients' mean age was 9.42 years (range 6-12.5 years). One patient initially suffered from metastasis and succumbed to the disease; another refused further treatment following chemotherapy and was lost to follow-up. Four patients underwent surgery and adjuvant radiotherapy successfully. At a mean follow-up of 3.78 years relapse-free and overall survival rates were 60% and 80% respectively. The aesthetic and functional outcome was satisfactory in all treated patients. In eligible cases the combination of chemotherapy with surgery and adjuvant radiotherapy results in optimal oncological and functional outcome for children with ES of the maxillofacial region. Metastasis and poor response to chemotherapy are the most important adverse prognostic factors.

Iatrou I ，Theologie-Lygidakis N ，Schoinohoriti O ，Tzermpos F ，Mylonas AI ... -  《-》

Local therapy in non-metastatic primary Ewing sarcoma of the mandible and maxilla in children.

Ewing sarcoma (ES) of the jaw bones comprises a small fraction of ES at all sites. Due to their rarity, a specific policy for local treatment is lacking. The aim of this study was to evaluate the local therapy for ES and recommend measures to individualize treatment options. Patients with primary non-metastatic ES of the jaw bones treated between August 2005 and February 2015 were analyzed. All patients received primary induction chemotherapy, following which lesions amenable to resection based on specific radiological criteria were resected; those with unresectable lesions were offered definitive radiotherapy. The maxilla was the primary site in 13 patients and the mandible in eight. The median age of patients was 11.6 years (range 5-17 years). Overall, surgery was performed in 17 patients and definitive radiotherapy was used in four patients. Postoperative radiotherapy was administered to 12 patients and was avoided in five patients with 100% tumour necrosis. The 3-year overall survival, event-free survival, and local control were 68.1%, 63.6%, and 80.2%, respectively. Mandible primary and a histological response to chemotherapy were significant prognostic factors. The stratification of patients based on radiological criteria aids in selecting local therapy. In eligible patients, surgery with contemporary reconstruction results in optimal oncological and functional outcomes. Surgery also has the added advantage of identifying patients who may not need radiotherapy.

Qureshi SS ，Bhagat M ，Laskar S ，Kembhavi S ，Vora T ，Ramadwar M ，Chinnaswamy G ，Prasad M ，Khanna N ，Shah S ，Talole S ... -  《-》

Prognosis of Ewing's sarcoma of the head and neck.

Mamede RM ，Mello FV ，Barbieri J 《OTOLARYNGOLOGY-HEAD AND NECK SURGERY》

[Ewing's sarcoma of the jaw. The value of multidisciplinary management. Apropos of 4 cases].

Baude-Brogniez A ，Baranzelli MC ，Ferri J ，Piot B ，Demaille MC ，Lecomte-Houcke M ，Mercier J ，Donazzan M ... -  《-》

Primary Ewing's sarcoma of the maxilla, a rare and curable localization: report of two new cases, successfully treated by radiotherapy and systemic chemotherapy.

Fiorillo A ，Tranfa F ，Canale G ，Fariello I ，D'Amore R ，De Chiara C ，Vassallo P ，Muto P ，De Rosa G ，Bonavolonta G ... -  《CANCER LETTERS》