Chronic stress and the introduction to captivity: How wild house sparrows (Passer domesticus) adjust to laboratory conditions.

The conditions of captivity can cause chronic stress in wild animals. Newly-captured animals may experience weight loss, elevated glucocorticoid hormones, increased heart rate, increased resting adrenomedullary activation, and an altered heart rate response to acute stressors. As captivity conditions persist, chronic stress may decrease as animals adjust to the stressors of captivity. In this study, house sparrows (Passer domesticus) were captured from the wild, fitted with heart rate transmitters in a minor surgical process, and individually housed in an indoor bird facility. Mass, baseline corticosterone, resting heart rate, resting adrenomedullary activation, and the acute heart rate response to a sudden noise were measured over the course of the first 6 weeks of captivity. Birds lost weight during the first weeks of captivity, which was regained by week 5. Baseline corticosterone peaked at day 7, decreased sharply by day 11, and continued to decrease throughout the 6 weeks. Although heart rate in the first 24 h could not be collected, daytime heart rate decreased from day 1 through day 20, where it reached a stable plateau. Daytime heart rate variability decreased through the entire 6 weeks, which may indicate a gradual shift from sympathetic to parasympathetic nervous system regulation of heart rate. The acute heart rate response to a sudden noise lasted longer at day 6 than earlier or later in captivity. In conclusion, the data indicate that the different physiological systems associated with chronic stress adjust to captivity over different timelines.

Fischer CP ，Wright-Lichter J ，Romero LM 《-》

Captivity influences immune responses, stress endocrinology, and organ size in house sparrows (Passer domesticus).

Studies using wild animals in laboratory-based research require bringing wild-captured organisms into a novel setting, which can have long-lasting impacts on physiology and behavior. In several species, captivity stimulates stress hormone production and can alter immune function. Despite this, there is little consensus on how captivity influences stress hormone regulation, or if captivity-induced changes in stress hormone production and regulation mediate changes in immune function. In this study, we investigate the influence of captivity on the physiology of a wild bird commonly-used in laboratory-based research, the house sparrow (Passer domesticus). We tested how captivity influences stress endocrinology, immune responses, and organ mass, and also investigated if the production or regulation of corticosterone, the main stress hormone in birds, correlated with changes in immunity. We found that baseline corticosterone concentrations and maximum capacity of the adrenals to secrete corticosterone increase following captivity and remain elevated after 9weeks of captivity. A measure of innate immune function, the bactericidal ability of plasma, also increased with time spent in captivity. Wound healing was also influenced by time spent in captivity, with birds taking almost 2days longer to heal if they were wounded after 3weeks in captivity when compared with birds that were wounded immediately upon capture. Additionally, captivity caused notable reductions in spleen and liver mass. Together, these results imply that captivity can have long-lasting effects on house sparrow corticosterone release and immune function, and suggest that even after 9weeks house sparrows do not acclimate physiologically to life in captivity.

Love AC ，Lovern MB ，DuRant SE 《-》

Captivity induces hyper-inflammation in the house sparrow (Passer domesticus).

Martin LB ，Kidd L ，Liebl AL ，Coon CA ... -  《-》

The effects of daily mitotane or diazepam treatment on the formation of chronic stress symptoms in newly captured wild house sparrows.

Wild animals brought into captivity frequently experience chronic stress and typically need a period of time to adjust to the conditions of captivity (restraint, artificial lighting, altered diet, human presence, etc.), to which they may never fully acclimate. Changes in mass, the hypothalamic-pituitary-adrenal axis and heart rate parameters have been observed over the first week in newly captive house sparrows (Passer domesticus). In this study, we tested the effects of two drugs, diazepam and mitotane, in preventing the chronic stress symptoms caused by captivity, compared with oil-injected control animals. Diazepam is an anxiolytic that is widely prescribed in humans and other animals and has been shown in some cases to reduce physiological stress. Mitotane is an agent that causes chemical adrenalectomy, reducing the body's capacity to produce glucocorticoid hormones. Our mitotane treatment did not cause the expected change in corticosterone concentrations. Baseline corticosterone was higher after a week in captivity regardless of the treatment group, while stress-induced corticosterone did not significantly increase above baseline after a week in captivity in any treatment group. However, mitotane treatment did have some physiological effects, as it reduced the resting heart rate and the duration of the heart rate response to a sudden noise. It also prevented the increase in nighttime activity that we observed in control animals. There was no effect of diazepam on corticosterone, resting heart rate, activity or heart rate response to a sudden noise, and no effect of either treatment on the sympathetic vs parasympathetic control of the resting heart rate. Together, these data suggest that mitotane, but not diazepam, can have a modest impact on helping house sparrows adapt to captive conditions. Easing the transition to captivity will likely make conservation efforts, such as initiating captive breeding programs, more successful.

Fischer CP ，Romero LM 《Conservation Physiology》

Experimentally reducing corticosterone mitigates rapid captivity effects on behavior, but not body composition, in a wild bird.

Lattin CR ，Pechenenko AV ，Carson RE 《-》