LncRNA ZEB1-AS1 predicts unfavorable prognosis in gastric cancer.

LncRNA ZEB1 Antisense 1 (ZEB1-AS1) has been suggested to be an oncogenic role in human hepatocellular carcinoma, osteosarcoma, glioma and esophageal carcinoma progression. However, the clinical significance and biological function of ZEB1-AS1 in gastric cancer is poorly understood. Levels of ZEB1-AS1 expression in gastric cancer tissues and cell lines were detected by qRT-PCR. Loss-of-function and gain-of-function studies were conducted to explore the biological function of ZEB1-AS1 in gastric cancer cells migration, invasion and EMT process. Rescued-function studies were performed to explore the association between ZEB1-AS1 and ZEB1 in gastric cancer cells migration, invasion and EMT process. ZEB1-AS1 was overexpressed in gastric cancer tissues and cell lines, and correlated with malignant status and prognosis in gastric cancer patients. ZEB1-AS1 regulated gastric cancer cells migration, invasion and EMT process. ZEB1-AS1 positively regulated ZEB1 expression in gastric cancer cells, and had a strongly positive correlation with ZEB1 expression in gastric cancer tissues. Rescued-function studies showed ZEB1 was critical for ZEB1-AS1 induced gastric cancer cells migration, invasion and EMT process. ZEB1-AS1 served as oncogenic roles in the regulation of gastric cancer cells migration, invasion and EMT process through modulating ZEB1.

Li Y ，Wen X ，Wang L ，Sun X ，Ma H ，Fu Z ，Li L ... -  《-》

Long non-coding RNA ZEB1-AS1 is associated with poor prognosis in gastric cancer and promotes cancer cell metastasis.

Liu XJ ，Li SL ，Li JS ，Lu H ，Yin LL ，Zheng WF ，Wang WC ... -  《-》

A Long Non-coding RNA Activated by Transforming Growth Factor-β is an Independent Prognostic Marker of Gastric Cancer.

Saito T ，Kurashige J ，Nambara S ，Komatsu H ，Hirata H ，Ueda M ，Sakimura S ，Uchi R ，Takano Y ，Shinden Y ，Iguchi T ，Eguchi H ，Ehata S ，Murakami K ，Sugimachi K ，Mimori K ... -  《-》

Expression of long non-coding RNA ZEB1-AS1 in esophageal squamous cell carcinoma and its correlation with tumor progression and patient survival.

Wang YL ，Bai Y ，Yao WJ ，Guo L ，Wang ZM ... -  《International Journal of Clinical and Experimental Pathology》

MiR-6872 host gene SEMA3B and its antisense lncRNA SEMA3B-AS1 function synergistically to suppress gastric cardia adenocarcinoma progression.

Guo W ，Liang X ，Liu L ，Guo Y ，Shen S ，Liang J ，Dong Z ... -  《-》