Comparison of T lymphocyte subsets in aplastic anemia and hypoplastic myelodysplastic syndromes.

This study aims to compare the proportion of peripheral blood T lymphocyte subsets and related blood cell and bone marrow cytology indexes between patients with aplastic anemia (AA) and hypoplastic myelodysplastic syndrome (hypo-MDS), and investigate the clinical identification significance. A total of 41 patients with AA and 46 patients with hypo-MDS were collected, and the proportions of peripheral blood T lymphocyte subsets, CD3-CD16/CD56+NK cells, CD3+CD57+T-LGL cells and CD19+B lymphocytes were detected by flow cytometry. The CD4+/CD8+ ratio decreased in the AA and hypo-MDS groups, and the difference was statistically significant when compared with that in the control group (P<0.05). However, there was no significant difference between AA and hypo-MDS groups (P>0.05). The proportions of CD3-CD16/CD56+NK cells and CD3+CD57+T-LGL cells in the hypo-MDS group were distinctly higher than those in the AA group (P<0.05). However, the proportion of CD19+B lymphocyte was obviously lower than that in the AA group (P<0.05). Furthermore, the proportions of reticulocytes, bone marrow progenitor cells and immature red blood cells in the hypo-MDS group were significantly more than those in the AA group (P<0.05), and the proportion of mature lymphocytes in the hypo-MDS group was distinctly lower than that in the AA group (P<0.05). Changes of T lymphocyte subsets and the proportions of large granular lymphocytes and B lymphocytes can be utilized as indexes in the differential diagnosis between AA and hypo-MDS.

Zhang HF ，Huang ZD ，Wu XR ，Li Q ，Yu ZF ... -  《-》

[Analysis of Lymphocyte Subsets in Peripheral Blood of Patients with Aplastic Anemia or Hypoplastic Myelodysplastic Syndrome].

Lv YF ，Yan ZY ，Chen NY ，Wu JH ，Liu B ，Wang GL ，Wang J ... -  《-》

Comparison of immunological abnormalities of lymphocytes in bone marrow in myelodysplastic syndrome (MDS) and aplastic anemia (AA).

Li X ，Xu F ，He Q ，Wu L ，Zhang Z ，Chang C ... -  《-》

[Changes and clinical significance of CD8(+) T cell subset in patients with aplastic anemia, myelodysplastic syndrome and acute myeloid leukemia].

Zhang JY ，Xu HZ ，Yin DM ，Feng XM ，Sui XH ，Cui B ，Ma CY ... -  《-》

[Changes of HLA-DR15 and immunoglobulin, T lymphocyte subsets in patients with aplastic anemia, myelodysplastic syndrome and their significance].

Cui JX ，Pei MF ，Zhang GS ，Xu M ... -  《-》