Esculentoside A inhibits LPS-induced acute kidney injury by activating PPAR-γ.

Acute kidney injury (AKI) is a major clinical problem associated with high morbidity and mortality. Esculentoside A (EsA), a kind of saponin isolated from the root of the Chinese herb Phytolaca esculenta, has been reported to have anti-inflammatory effect. In this study, we aimed to investigate the protective effects of EsA on LPS-induced AKI in mice. The protective effects of EsA was evaluated by detecting kidney histological change, blood urea nitrogen (BUN) and creatinine levels, and inflammatory cytokines production. The results showed that EsA significantly attenuated LPS-induced kidney histological change, as well as BUN and creatinine levels. EsA also inhibited LPS-induced TNF-α, IL-1β, and IL-6 production. LPS-induced NF-κB activation was significantly suppressed by treatment of EsA. In addition, EsA up-regulated the expression of PPAR-γ in a dose-dependent manner. In conclusion, EsA protected mice effectively from LPS-induced AKI by PPAR-γ, which subsequently inhibited LPS-induced inflammatory response.

Chen DZ ，Chen LQ ，Lin MX ，Gong YQ ，Ying BY ，Wei DZ ... -  《-》

Esculentoside A inhibits LPS-induced BV2 microglia activation through activating PPAR-γ.

Neuroinflammation has been recognized as a factor in the pathogenesis of neurodegenerative diseases. Esculentoside A (EsA), a saponin isolated from Phytolacca esculenta, has been reported to have anti-inflammatory activity. However, little research has been reported on the anti-neuroinflammatory effects of EsA. EsA concentration-dependently suppressed LPS-induced TNF-α, IL-1β, and PGE2 production. LPS-induced NF-κB activation was inhibited by treatment of EsA. Furthermore, EsA concentration-dependently up-regulated the expression of PPAR-γ. In addition, GW9662, a specific PPAR-γ inhibitor, reversed the anti-inflammatory effects of EsA. In conclusion, these results indicate that EsA exerts anti-inflammatory effects by activating PPAR-γ.

Li-Hua D ，Yan L ，Shi-Ji W ，Guang W ，Lu-Lu S ，Xue-Feng P ，Pengda S ... -  《-》

Esculentoside A ameliorates cecal ligation and puncture-induced acute kidney injury in rats.

Sun G ，Yang W ，Zhang Y ，Zhao M ... -  《-》

Licochalcone A Attenuates Lipopolysaccharide-Induced Acute Kidney Injury by Inhibiting NF-κB Activation.

Hu J ，Liu J 《-》

The protective effect of Esculentoside A on experimental acute liver injury in mice.

Zhang F ，Wang X ，Qiu X ，Wang J ，Fang H ，Wang Z ，Sun Y ，Xia Z ... -  《-》