Executive summary of the 2017 KDIGO Chronic Kidney Disease-Mineral and Bone Disorder (CKD-MBD) Guideline Update: what's changed and why it matters.

The KDIGO 2017 Clinical Practice Guideline Update for the Diagnosis, Evaluation, Prevention, and Treatment of CKD-MBD represents a selective update of the prior CKD-MBD Guideline published in 2009. This update, along with the 2009 publication, is intended to assist the practitioner caring for adults and children with chronic kidney disease (CKD), those on chronic dialysis therapy, or individuals with a kidney transplant. This review highlights key aspects of the 2017 CKD-MBD Guideline Update, with an emphasis on the rationale for the changes made to the original guideline document. Topic areas encompassing updated recommendations include diagnosis of bone abnormalities in CKD-mineral and bone disorder (MBD), treatment of CKD-MBD by targeting phosphate lowering and calcium maintenance, treatment of abnormalities in parathyroid hormone in CKD-MBD, treatment of bone abnormalities by antiresorptives and other osteoporosis therapies, and evaluation and treatment of kidney transplant bone disease.

Ketteler M ，Block GA ，Evenepoel P ，Fukagawa M ，Herzog CA ，McCann L ，Moe SM ，Shroff R ，Tonelli MA ，Toussaint ND ，Vervloet MG ，Leonard MB ... -  《-》

KDOQI US Commentary on the 2017 KDIGO Clinical Practice Guideline Update for the Diagnosis, Evaluation, Prevention, and Treatment of Chronic Kidney Disease-Mineral and Bone Disorder (CKD-MBD).

Chronic kidney disease-mineral and bone disorder (CKD-MBD) encompasses laboratory and bone abnormalities and vascular calcification and has deleterious effects on clinical outcomes. KDOQI (Kidney Disease Outcomes Quality Initiative), an initiative of the National Kidney Foundation, addressed this issue with the publication of a clinical practice guideline for bone metabolism and disease in CKD in 2003, and 2 years later, a new definition and classification scheme for CKD-MBD was developed following a KDIGO (Kidney Disease: Improving Global Outcomes) Controversies Conference. The initial KDIGO guideline on CKD-MBD was then published in 2009. New evidence was subsequently reviewed at the 2013 KDIGO Controversies Conference, and in 2017, KDIGO issued a clinical practice guideline update for the diagnosis, evaluation, prevention, and treatment of CKD-MBD. This commentary presents the views of the KDOQI CKD-MBD work group convened by the National Kidney Foundation. The KDOQI work group agrees with most of the KDIGO guideline update recommendations, particularly the suggestions regarding bone mineral density testing, joint assessments of longitudinal trends in mineral metabolism markers, and dietary phosphate counseling focused on phosphate additives. However, the KDOQI work group has some concerns about the suggestions related to hypocalcemia and hypercalcemia, phosphate-binder choice, and treatment of abnormal parathyroid hormone concentrations. The overall goal of this commentary is to provide a broad discussion for the US nephrology community regarding CKD-MBD and its diagnosis, prevention, and treatment.

Isakova T ，Nickolas TL ，Denburg M ，Yarlagadda S ，Weiner DE ，Gutiérrez OM ，Bansal V ，Rosas SE ，Nigwekar S ，Yee J ，Kramer H ... -  《-》

Management of CKD-MBD in non-dialysis patients under regular nephrology care: a prospective multicenter study.

Gallieni M ，De Luca N ，Santoro D ，Meneghel G ，Formica M ，Grandaliano G ，Pizzarelli F ，Cossu M ，Segoloni G ，Quintaliani G ，Di Giulio S ，Pisani A ，Malaguti M ，Marseglia C ，Oldrizzi L ，Pacilio M ，Conte G ，Dal Canton A ，Minutolo R ... -  《-》

Treatment of hyperphosphatemia: the dangers of aiming for normal PTH levels.

Haffner D ，Leifheit-Nestler M 《-》

Diagnosis, Evaluation, Prevention, and Treatment of Chronic Kidney Disease-Mineral and Bone Disorder: Synopsis of the Kidney Disease: Improving Global Outcomes 2017 Clinical Practice Guideline Update.

Ketteler M ，Block GA ，Evenepoel P ，Fukagawa M ，Herzog CA ，McCann L ，Moe SM ，Shroff R ，Tonelli MA ，Toussaint ND ，Vervloet MG ，Leonard MB ... -  《-》