Anticoagulant bridging in left-sided mechanical heart valve patients.

In preparation for an invasive procedure with a high bleeding risk, patients with a mechanical heart valve temporarily have to discontinue their anticoagulant therapy and are usually bridged with either intravenous unfractionated heparin (UFH) or subcutaneous low-molecular-weight heparin (LMWH). In this study we retrospectively analyzed the safety of UFH versus LMWH as bridging strategy in left-sided mechanical heart valve patients. We performed a retrospective multicenter study in four surgical centers in The Netherlands. Patients with a mechanical heart valve implantation bridged from January 2010 until January 2015 were included. The cumulative incidence of adverse events in the 30days following the procedure was recorded. Main outcomes were major bleeding according to International Society on Thrombosis and Haemostasis (ISTH) criteria, symptomatic thromboembolism, and mortality. In total, 238 (174 aortic, 42 mitral, 22 aortic+mitral) bridging episodes were included. The incidence of major bleeding was 16 (19%) events in the UFH group versus 29 (19%) events in the LMWH group (p=0.97). Incidences of thromboembolism were 2 (2.4%) versus 1 (0.6%). The incidence of death was 1 (1.2%) patient in the UFH group versus 3 (1.9%) patients in the LMWH group. More than 50% of all bleeding complications were categorized as a major bleeding. Bridging anticoagulation in patients with aortic and mitral mechanical valves is associated with considerable risk, but no difference was apparent between UFH and LMWH strategy. The rate of thromboembolism and death was low with either strategy and the vast majority of adverse events were bleedings.

Hart EA ，Jansen R ，Meijs TA ，Bouma BJ ，Riezebos RK ，Tanis W ，van Boven WJ ，Hindori V ，Wiersma N ，Dessing T ，Westerink J ，Chamuleau SA ... -  《-》

Comparison of different bridging anticoagulation therapies used after mechanical heart valve replacement in Chinese patients - a prospective cohort study.

Li BX ，Liu SD ，Qi L ，Sun S ，Sun W ，Li YM ，Song B ，Wu XA ... -  《Journal of Cardiothoracic Surgery》

Peri-procedural anticoagulation management of mechanical prosthetic heart valve patients.

Daniels PR ，McBane RD ，Litin SC ，Ward SA ，Hodge DO ，Dowling NF ，Heit JA ... -  《-》

A meta-analysis of bridging anticoagulation between low molecular weight heparin and heparin.

Tao E ，Luo YL ，Tao Z ，Wan L ... -  《-》

Clinical outcomes with unfractionated heparin or low-molecular-weight heparin as bridging therapy in patients on long-term oral anticoagulants: the REGIMEN registry.

Spyropoulos AC ，Turpie AG ，Dunn AS ，Spandorfer J ，Douketis J ，Jacobson A ，Frost FJ ，REGIMEN Investigators ... -  《-》