Linking metabolic reprogramming to therapy resistance in cancer.

Metabolic rearrangements are essential to satisfy the different requirements of cancer cells during tumorigenesis and recent studies have highlighted a role for such metabolic reprogramming in response and adaptation to therapies. However, therapy-resistant experimental models have been described to be either glycolysis-dependent or OXPHOS-addicted. Here we discuss the recent literature on metabolic reprogramming of cancer in therapy resistance with a plausible explanation of the observed differences which collectively indicate that dis-regulated metabolic pathways could be considered potential therapeutic targets in tumors resistant to conventional therapy.

Morandi A ，Indraccolo S 《BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER》

Metabolic reprogramming: the emerging concept and associated therapeutic strategies.

Yoshida GJ 《JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH》

The ERK and JNK pathways in the regulation of metabolic reprogramming.

Papa S ，Choy PM ，Bubici C 《-》

Reprogramming of central carbon metabolism in cancer stem cells.

Cancer metabolism has been studied for years and adopted in the clinic for monitoring disease progression and therapy response. Despite our growing knowledge of a distinctly altered metabolic behavior in cancer, drugs targeting cancer metabolism have remained less than promising. Recent efforts in cancer stem cell (CSC) biology suggest that a subpopulation of tumor-initiating cells within the tumor bulk represents the root of tumor recurrence and therapy resistance. In recent years, metabolic phenotype of CSCs of various tumor types has been identified. This breakthrough has shed light on the underlying mechanism by which CSCs maintain stemness, confer resistance to therapies and initiate tumor relapse. The distinct metabolic characteristics of CSCs compared to non-CSCs provide an opportunity to target CSCs more specifically and have become a major focus in cancer research in recent years with substantial efforts conducted towards discovering clinical targets. This perspective article summarizes the current knowledge of CSC metabolism in carcinogenesis and highlights the potential of targeting CSC metabolism for therapy.

Wong TL ，Che N ，Ma S 《-》

Cancer proliferation and therapy: the Warburg effect and quantum metabolism.

Demetrius LA ，Coy JF ，Tuszynski JA 《Theoretical Biology and Medical Modelling》