The influence of human papillomavirus on nasopharyngeal carcinoma in Japan.

Although Japan is a non-endemic area with nasopharyngeal carcinoma (NPC), the proportion of WHO type I NPC in Japan are different from that in non-endemic areas such as North America and Europe. Recently, it is said that not only Epstein-Barr virus (EBV) but also human papillomavirus (HPV) has an influence on NPC in non-endemic areas. The aim of this study is to clarify the influence of HPV on NPC in Japan. Paraffin-embedded tumor specimens were available for 59 patients with NPC diagnosed between 1996 and 2015. We detected the virus status by p16 immunohistochemistry, HPV PCR, and in situ hybridization for Epstein-Barr virus (EBV)-encoded RNA. Kaplan-Meier curves were used to compare the overall survival by viral status. Among the 59 patients, 49 (83%) were EBV-positive/HPV-negative, 2 (3%) were EBV-positive/HPV-positive, and 8 (16%) were EBV-negative/HPV-negative. All HPV-positive NPCs were co-infected with EBV. There were no significant differences between the overall survival in the three groups (p=0.111). In Japan, HPV was detected in a few patients with NPC, and we suggest that HPV has no influence on NPC carcinogenesis in this population.

Kano M ，Kondo S ，Wakisaka N ，Moriyama-Kita M ，Nakanishi Y ，Endo K ，Murono S ，Nakamura H ，Yoshizaki T ... -  《-》

Epstein-Barr virus and human papillomavirus infections and genotype distribution in head and neck cancers.

Deng Z ，Uehara T ，Maeda H ，Hasegawa M ，Matayoshi S ，Kiyuna A ，Agena S ，Pan X ，Zhang C ，Yamashita Y ，Xie M ，Suzuki M ... -  《-》

Human papillomavirus and Epstein-Barr virus in nasopharyngeal carcinoma in a non-endemic eastern european population.

Svajdler M Jr ，Kaspirkova J ，Mezencev R ，Laco J ，Torday T ，Dubinsky P ，Straka L ，Ondic O ，Michal M ，Skalova A ... -  《-》

Human papillomavirus may be common within nasopharyngeal carcinoma of Caucasian Americans: investigation of Epstein-Barr virus and human papillomavirus in eastern and western nasopharyngeal carcinoma using ligation-dependent polymerase chain reaction.

Punwaney R ，Brandwein MS ，Zhang DY ，Urken ML ，Cheng R ，Park CS ，Li HB ，Li X ... -  《-》

Programmed Death-Ligand 1 Expression, Microsatellite Instability, Epstein-Barr Virus, and Human Papillomavirus in Nasopharyngeal Carcinomas of Patients from the Philippines.

Chang AMV ，Chiosea SI ，Altman A ，Pagdanganan HA ，Ma C ... -  《-》