Prognostic Significance of Progesterone Receptor Expression in Estrogen-Receptor Positive, HER2-Negative, Node-Negative Invasive Breast Cancer With a Low Ki-67 Labeling Index.

We showed the clinical implications of the Ki-67 labeling index (LI) in hormone receptor (HR)-positive, HER2-negative (HER2-) breast cancer patients with lower risk (luminal A [LA]-like) and higher risk (luminal B [LB]-like) subtypes. Three hundred sixty-nine patients with HR+, HER2- cancers were eligible and we dichotomized these patients into LA-like and LB-like according to Ki-67 LI (14% cutoff) and analyzed prognostic significance of progesterone receptor (PR) expression. Of 205 LA-like and 163 LB-like subtypes, PR was positive in 149 (73%) and 103 (63%). PR expression was a prognostic factor in the LA-like subtype but not in the LB-like subtype. In LA/PR+, LA/PR-, and LB-like subtypes, the 12-year disease-free survival (DFS) rates were 94.8%, 81.6%, and 79.7% (P = .03), and breast cancer-specific survival (BCSS) rates were 98.4%, 97.4%, and 92.0%, respectively (P = .05). Late recurrence occurred in LA/PR- subtype, and differences in prognosis between LA/PR+ and LA/PR- subtypes emerged >5 years after surgery. Twelve-year DFS rates of the LA/PR- subtype were almost equal to those of the LB-like subtype, whereas 12-year BCSS of the LA/PR- subtype was superior to that of the LB-like subtype. In multivariate analysis, PR expression and tumor size were significant or nearly significant prognostic factors. PR expression and tumor size were independent prognostic factors in the LA-like subtype, and the LA/PR- subtype had the higher risk of recurrence, especially late recurrence, than the LA/PR+ subtype. In LA-like breast cancers, stratification of prognosis according to PR expression and tumor size is important.

Ono M ，Tsuda H ，Yoshida M ，Shimizu C ，Kinoshita T ，Tamura K ... -  《-》

Prognostic value of phosphorylated HER2 in HER2-positive breast cancer patients treated with adjuvant trastuzumab.

Kurebayashi J ，Kanomata N ，Yamashita T ，Shimo T ，Mizutoh A ，Moriya T ，Sonoo H ... -  《-》

Ki-67 is a prognostic marker for hormone receptor positive tumors.

Pérez-López ME ，García-Gómez J ，Alves MT ，Paradela A ，García-Mata J ，García-Caballero T ... -  《-》

Prognostic significance of geminin expression levels in Ki67-high subset of estrogen receptor-positive and HER2-negative breast cancers.

Yagi T ，Inoue N ，Yanai A ，Murase K ，Imamura M ，Miyagawa Y ，Enomoto Y ，Nishimukai A ，Takatsuka Y ，Hirota S ，Akazawa K ，Miyoshi Y ... -  《-》

Prognostic Value of Tumor-Infiltrating Lymphocyte Density Assessed Using a Standardized Method Based on Molecular Subtypes and Adjuvant Chemotherapy in Invasive Breast Cancer.

Jang N ，Kwon HJ ，Park MH ，Kang SH ，Bae YK ... -  《-》