Anti-Ma and anti-Ma2-associated paraneoplastic neurological syndromes.

Analyse the clinical profile, associated tumour types, and response to treatment of paraneoplastic neurological syndromes associated with antibodies against Ma proteins. A retrospective study of patients with antibodies against Ma proteins identified in a neuroimmunology laboratory of reference. Of the 32 patients identified, 20 showed reactivity against Ma2 only (anti-Ma2 antibodies), 11 against Ma1 and Ma2 (anti-Ma antibodies), and 1 with reactivity against Ma1 only (anti-Ma1 antibodies). The most common clinical presentations were limbic encephalopathy, diencephalic dysfunction, or brainstem encephalopathy, frequently appearing as a combination of these features. Three patients had isolated cerebellar dysfunction with anti-Ma antibodies, and 2 exhibited peripheral nervous system syndrome with anti-Ma2 antibodies. Testicular tumours were the most common neoplasms (40%) in the anti-Ma2 cases. In the group associated with anti-Ma1 antibodies, the most common were lung tumours (36%), followed by testicular tumours. All idiopathic cases were reactive to Ma2. The clinical outcome was significantly better in the anti-Ma2 group. The patient with anti-Ma1 presented with limbic encephalitis and brainstem dysfunction associated with lymphoepithelioma of the bladder. Specifically determining the different reactivities of anti-Ma protein antibodies in order to differentiate between Ma1 and Ma2 antibodies is important because anti-Ma2-associated paraneoplastic syndromes have a better outcome. Lastly, this study is the first to confirm that there may be cases that react exclusively to antibodies against Ma1.

Ortega Suero G ，Sola-Valls N ，Escudero D ，Saiz A ，Graus F ... -  《-》

Clinical analysis of anti-Ma2-associated encephalitis.

Dalmau J ，Graus F ，Villarejo A ，Posner JB ，Blumenthal D ，Thiessen B ，Saiz A ，Meneses P ，Rosenfeld MR ... -  《-》

[Anti-Ma2-associated encephalitis and paraneoplastic limbic encephalitis].

Yamamoto T ，Tsuji S 《-》

[Limbic encephalitis with antibodies against intracellular antigens].

Morita A ，Kamei S 《-》

A serologic marker of paraneoplastic limbic and brain-stem encephalitis in patients with testicular cancer.

Voltz R ，Gultekin SH ，Rosenfeld MR ，Gerstner E ，Eichen J ，Posner JB ，Dalmau J ... -  《NEW ENGLAND JOURNAL OF MEDICINE》