Biosurfactant/s from Lactobacilli species: Properties, challenges and potential biomedical applications.

Lactic acid bacteria are generally believed to have positive roles in maintaining good health and immune system in humans. A number of Lactobacilli spp. are known to produce important metabolites, among which biosurfactants in particular have shown antimicrobial activity against several pathogens in the intestinal tract and female urogenital tract partly through interfering with biofilm formation and adhesion to the epithelial cells surfaces. Around 46 reports are documented on biosurfactant production from Lactobacillus spp. of which six can be broadly classified as cell free biosurfactant and 40 as cell associated biosurfactants and only approximately 50% of those have reported on the structural composition which, in order of occurrence were mainly proteinaceous, glycolipidic, glycoproteins, or glycolipopeptides in nature. Due to the proteinaceous nature, most biosurfactant produced by strains of Lactobacillus are generally believed to be surlactin type with high potential toward impeding pathogens adherence. Researchers have recently focused on the anti-adhesive and antibiofilm properties of Lactobacilli-derived biosurfactants. This review briefly discusses the significance of Lactobacilli-derived biosurfactants and their potential applications in various fields. In addition, we highlight the exceptional prospects and challenges in fermentation economics of Lactobacillus spp.-derived biosurfactants' production processes.

Satpute SK ，Kulkarni GR ，Banpurkar AG ，Banat IM ，Mone NS ，Patil RH ，Cameotra SS ... -  《-》

Biological and physicochemical properties of biosurfactants produced by Lactobacillus jensenii P(6A) and Lactobacillus gasseri P(65).

Morais IMC ，Cordeiro AL ，Teixeira GS ，Domingues VS ，Nardi RMD ，Monteiro AS ，Alves RJ ，Siqueira EP ，Santos VL ... -  《Microbial Cell Factories》

Antimicrobial and anti-adhesive properties of biosurfactant produced by lactobacilli isolates, biofilm formation and aggregation ability.

Zakaria Gomaa E 《-》

Inhibition of pathogenic bacterial biofilms on PDMS based implants by L. acidophilus derived biosurfactant.

Satpute SK ，Mone NS ，Das P ，Banat IM ，Banpurkar AG ... -  《BMC MICROBIOLOGY》

Antimicrobial and antibiofilm potential of biosurfactants isolated from lactobacilli against multi-drug-resistant pathogens.

Sambanthamoorthy K ，Feng X ，Patel R ，Patel S ，Paranavitana C ... -  《BMC MICROBIOLOGY》