GOLPH3 and oncogenesis: What is the molecular link?

The Golgi phosphoprotein 3 (GOLPH3) is encoded by a gene that is located in a region of the human genome that is often amplified in different solid tumours. GOLPH3, an evolutionary conserved phosphatidylinositol 4-phosphate (PI4P) binding protein, is mainly localised at trans Golgi network (TGN). It regulates several cellular functions like Golgi vesicular trafficking, Golgi glycosylation and mitochondrial cardiolipin production. Recently, GOLPH3 was discovered to be part of the DNA damage response signalling pathway, with a role in cell survival following DNA damage. In this review, we will explore the cellular functions regulated by GOLPH3 and discuss if and how they contribute to the oncogenic activity of this intriguing Golgi localized oncoprotein.

Rizzo R ，Parashuraman S ，D'Angelo G ，Luini A ... -  《-》

GOLPH3 Regulates EGFR in T98G Glioblastoma Cells by Modulating Its Glycosylation and Ubiquitylation.

Arriagada C ，Cavieres VA ，Luchsinger C ，González AE ，Muñoz VC ，Cancino J ，Burgos PV ，Mardones GA ... -  《-》

Distinct Biochemical Pools of Golgi Phosphoprotein 3 in the Human Breast Cancer Cell Lines MCF7 and MDA-MB-231.

Tenorio MJ ，Ross BH ，Luchsinger C ，Rivera-Dictter A ，Arriagada C ，Acuña D ，Aguilar M ，Cavieres V ，Burgos PV ，Ehrenfeld P ，Mardones GA ... -  《PLoS One》

GOLPH3 links the Golgi, DNA damage, and cancer.

GOLPH3 is the first example of an oncogene that functions in secretory trafficking at the Golgi. The discovery of GOLPH3's roles in both cancer and Golgi trafficking raises questions about how GOLPH3 and the Golgi contribute to cancer. Our recent investigation of the regulation of GOLPH3 revealed a surprising response by the Golgi upon DNA damage that is mediated by DNA-PK and GOLPH3. These results provide new insight into the DNA damage response with important implications for understanding the cellular response to standard cancer therapeutic agents.

Buschman MD ，Rahajeng J ，Field SJ 《-》

Role of phosphatidylinositol 4-phosphate (PI4P) and its binding protein GOLPH3 in hepatitis C virus secretion.

Bishé B ，Syed GH ，Field SJ ，Siddiqui A ... -  《-》