The GeneCards Suite: From Gene Data Mining to Disease Genome Sequence Analyses.

GeneCards, the human gene compendium, enables researchers to effectively navigate and inter-relate the wide universe of human genes, diseases, variants, proteins, cells, and biological pathways. Our recently launched Version 4 has a revamped infrastructure facilitating faster data updates, better-targeted data queries, and friendlier user experience. It also provides a stronger foundation for the GeneCards suite of companion databases and analysis tools. Improved data unification includes gene-disease links via MalaCards and merged biological pathways via PathCards, as well as drug information and proteome expression. VarElect, another suite member, is a phenotype prioritizer for next-generation sequencing, leveraging the GeneCards and MalaCards knowledgebase. It automatically infers direct and indirect scored associations between hundreds or even thousands of variant-containing genes and disease phenotype terms. VarElect's capabilities, either independently or within TGex, our comprehensive variant analysis pipeline, help prepare for the challenge of clinical projects that involve thousands of exome/genome NGS analyses. © 2016 by John Wiley & Sons, Inc.

Stelzer G ，Rosen N ，Plaschkes I ，Zimmerman S ，Twik M ，Fishilevich S ，Stein TI ，Nudel R ，Lieder I ，Mazor Y ，Kaplan S ，Dahary D ，Warshawsky D ，Guan-Golan Y ，Kohn A ，Rappaport N ，Safran M ，Lancet D ... -  《-》

VarElect: the phenotype-based variation prioritizer of the GeneCards Suite.

Stelzer G ，Plaschkes I ，Oz-Levi D ，Alkelai A ，Olender T ，Zimmerman S ，Twik M ，Belinky F ，Fishilevich S ，Nudel R ，Guan-Golan Y ，Warshawsky D ，Dahary D ，Kohn A ，Mazor Y ，Kaplan S ，Iny Stein T ，Baris HN ，Rappaport N ，Safran M ，Lancet D ... -  《BMC GENOMICS》

Rational confederation of genes and diseases: NGS interpretation via GeneCards, MalaCards and VarElect.

Rappaport N ，Fishilevich S ，Nudel R ，Twik M ，Belinky F ，Plaschkes I ，Stein TI ，Cohen D ，Oz-Levi D ，Safran M ，Lancet D ... -  《Biomedical Engineering Online》

Genome analysis and knowledge-driven variant interpretation with TGex.

Dahary D ，Golan Y ，Mazor Y ，Zelig O ，Barshir R ，Twik M ，Iny Stein T ，Rosner G ，Kariv R ，Chen F ，Zhang Q ，Shen Y ，Safran M ，Lancet D ，Fishilevich S ... -  《BMC Medical Genomics》

GeneAnalytics: An Integrative Gene Set Analysis Tool for Next Generation Sequencing, RNAseq and Microarray Data.

Ben-Ari Fuchs S ，Lieder I ，Stelzer G ，Mazor Y ，Buzhor E ，Kaplan S ，Bogoch Y ，Plaschkes I ，Shitrit A ，Rappaport N ，Kohn A ，Edgar R ，Shenhav L ，Safran M ，Lancet D ，Guan-Golan Y ，Warshawsky D ，Shtrichman R ... -  《-》