The EQ-5D-5L health status questionnaire in COPD: validity, responsiveness and minimum important difference.

The EQ-5D, a generic health status questionnaire that is widely used in health economic evaluation, was recently expanded to the EQ-5D-5L to address criticisms of unresponsiveness and ceiling effect. To describe the validity, responsiveness and minimum important difference of the EQ-5D-5L in COPD. Study 1: The validity of the EQ-5D-5L utility index and visual analogue scale (EQ-VAS) was compared with four established disease-specific health status questionnaires and other measures of disease severity in 616 stable outpatients with COPD. Study 2: The EQ-5D-5L utility index and EQ-VAS were measured in 324 patients with COPD before and after 8 weeks of pulmonary rehabilitation. Distribution and anchor-based approaches were used to estimate the minimum important difference. There were moderate-to-strong correlations between utility index and EQ-VAS with disease-specific questionnaires (Pearson's r=0.47-0.72). A ceiling effect was seen in 7% and 2.6% of utility index and EQ-VAS. Utility index decreased (worsening health status) with indices of worsening disease severity. With rehabilitation, mean (95% CI) changes in utility index and EQ-VAS were 0.065 (0.047 to 0.083) and 8.6 (6.5 to 10.7), respectively, with standardised response means of 0.39 and 0.44. The mean (range) anchor estimates of the minimum important difference for utility index and EQ-VAS were 0.051 (0.037 to 0.063) and 6.9 (6.5 to 8.0), respectively. The EQ-5D-5L is a valid and responsive measure of health status in COPD and may provide useful additional cost-effectiveness data in clinical trials.

Nolan CM ，Longworth L ，Lord J ，Canavan JL ，Jones SE ，Kon SS ，Man WD ... -  《-》

Validity of EQ-5D utility index and minimal clinically important difference estimation among patients with chronic obstructive pulmonary disease.

Bae E ，Choi SE ，Lee H ，Shin G ，Kang D ... -  《BMC Pulmonary Medicine》

Validity, responsiveness, and minimal clinically important difference of EQ-5D-5L in stroke patients undergoing rehabilitation.

Chen P ，Lin KC ，Liing RJ ，Wu CY ，Chen CL ，Chang KC ... -  《-》

Measuring health-related quality of life in chronic obstructive pulmonary disease: properties of the EQ-5D-5L and PROMIS-43 short form.

Lin FJ ，Pickard AS ，Krishnan JA ，Joo MJ ，Au DH ，Carson SS ，Gillespie S ，Henderson AG ，Lindenauer PK ，McBurnie MA ，Mularski RA ，Naureckas ET ，Vollmer WM ，Lee TA ，CONCERT Consortium ... -  《BMC Medical Research Methodology》

Does quality of life of COPD patients as measured by the generic EuroQol five-dimension questionnaire differentiate between COPD severity stages?

Rutten-van Mölken MP ，Oostenbrink JB ，Tashkin DP ，Burkhart D ，Monz BU ... -  《CHEST》