Effects of methylphenidate on body index and physical fitness in Korean children with attention deficit hyperactivity disorder.

The side effects of methylphenidate (MPH) on growth remain a controversial concern. This study aimed to investigate the effect of MPH on clinical symptoms, growth, and physical fitness in Korean children. Fifty male children with attention deficit hyperactivity disorder (ADHD) treated with methylphenidate (MPH-ADHD), 69 MPH-naïve male children with ADHD (Naïve-ADHD), and 60 age-matched and sex-matched healthy control subjects were recruited. Intelligence quotient (IQ), clinical symptoms of ADHD, body index (height, weight, and body mass index [BMI]), and physical fitness (muscular strength, endurance, flexibility, agility, speed, and balance) were assessed. Total IQ and performance IQ scores were significantly different among the three groups, as were mean Korean Attention Deficit Hyperactivity Disorder (K-ARS)-total, K-ARS-inattention, and K-ARS-hyperactivity scores. There was no significant difference in height, weight, or BMI among the three groups. There were significant differences in skill-related fitness scores for balance (healthy controls > MPH-ADHD > Naïve-ADHD) and agility shuttle test time (healthy controls < MPH-ADHD < Naïve-ADHD). Our findings support the effectiveness of MPH treatment for improving IQ, attention, and balance and agility measures of skill-related fitness in Korean children with ADHD. MPH was not associated with growth delays in height, weight, and BMI.

Kang KD ，Yun SW ，Chung U ，Kim TH ，Park JH ，Park IH ，Han DH ... -  《-》

Sex differences in attentional performance and their modulation by methylphenidate in children with attention-deficit/hyperactivity disorder.

Günther T ，Herpertz-Dahlmann B ，Konrad K 《-》

Long-term effects of stimulants on neurocognitive performance of Taiwanese children with attention-deficit/hyperactivity disorder.

Tsai CS ，Huang YS ，Wu CL ，Hwang FM ，Young KB ，Tsai MH ，Chu SM ... -  《BMC Psychiatry》

Methylphenidate normalises activation and functional connectivity deficits in attention and motivation networks in medication-naïve children with ADHD during a rewarded continuous performance task.

Rubia K ，Halari R ，Cubillo A ，Mohammad AM ，Brammer M ，Taylor E ... -  《-》

Weight, Height, and Body Mass Index in Patients with Attention-Deficit/Hyperactivity Disorder Treated with Methylphenidate.

Díez-Suárez A ，Vallejo-Valdivielso M ，Marín-Méndez JJ ，de Castro-Manglano P ，Soutullo CA ... -  《-》